ArticleNature2026
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance.
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In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Dysregulated mScience advances · 2026Article
- Intermittent time-restricted feeding recapitulates the physiological benefits of daily time-restricted feeding in male mice with chronic metabolic disease.Molecular metabolism · 2026Article
- Microplastics Exacerbate Cadmium-Induced Hepatotoxicity via the IRE1α/TXNIP/NLRP3 Axis-Driven Endoplasmic Reticulum Stress and Pyroptosis.Veterinary sciences · 2026Article
- The versatile interplay between steatotic liver disease and liver cancer.Nature reviews. Cancer · 2026Review
- Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.Molecular cancer · 2026Review
- Learning from plants: is it possible to make an animal organism a non-host for cancer?Frontiers in oncology · 2026Article
- Targeting the unfolded protein response in cancer: mechanisms, small-molecule inhibitors, and translational challenges.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
98 authors.
Xin Li *Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Cynthia Lebeaupin *Center for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. cynthia.lebeaupin@gmail.com.ORCID 0000-0003-1609-5676
Aikaterini KadianakiDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0009-0004-4549-2018
Clementine Druelle-CedanoCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-4519-5660
Niklas VesperDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0009-0006-8165-0612
Charlotte RennertDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2186-2606
Júlia Huguet-PradellLiver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0003-1489-356X
Borja Gomez RamosDivision of Cell Fate Engineering and Disease Modeling, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.
Chaofan FanDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Robert Stefan PiecykDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.ORCID 0009-0002-1912-4487
Laimdota ZizmareWerner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.ORCID 0000-0001-7208-3659
Pierluigi RamadoriDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-6581-9648
Luqing LiDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lukas FrickInstitute of Neuropathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Menjie QiuM3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-0342-3661
Cangang ZhangDepartment of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Luiza Martins Nascentes MeloDepartment of Dermatology, University Hospital Essen, Essen, Germany.ORCID 0000-0002-5980-5220
Vikas Prakash RanvirDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-0437-6908
Peng ShenDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0009-0001-5723-8744
Johannes HanselmannM3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Jan KoslaDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Mirian Fernández-VaqueroDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-2781-5643
Mihael VucurDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty at Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0003-4078-1668
Praveen BaskaranQuantitative Biology Center (QBiC), Eberhard Karls University Tübingen, Tübingen, Germany.
Xuanwen BaoDepartment of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Olivia I ColemanChair of Nutrition and Immunology, Technische Universität München, Freising, Germany.ORCID 0000-0002-4075-7820
Yingyue TangInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Miray CetinFaculty of Biosciences, Heidelberg University, Heidelberg, Germany.ORCID 0009-0001-7711-0211
Zhouji ChenCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Insook JangCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0001-7567-3849
Stefania Del PreteDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1806-1819
Mohammad RahbariDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-1133-2134
Peng ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Timothy V PhamCenter for Novel Therapeutics and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Yushan HouState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Institute of Lifeomics, Beijing, China.
Aihua SunState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Institute of Lifeomics, Beijing, China.ORCID 0000-0001-7931-6662
Li GuLaboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5812-9024
Laura C KimAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8229-2745
Ulrike RothermelDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Danijela HeideDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Adnan AliDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Suchira GallageDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1956-3597
Nana Talvard-BallandDepartment of Hematology and Oncology, Freiburg University Medical Centre, Freiburg, Germany.ORCID 0000-0001-8590-6351
Marta Piqué-GiliLiver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Albert Gris-OliverLiver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0003-1802-9541
Alessio BevilacquaDepartment of Oncology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0001-7009-4362
Lisa SchlickerDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Alec DuffeyCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Kristian UngerDepartment of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Marta SzydlowskaDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny HetzerDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Duncan T OdomDivision of Regulatory Genomics and Cancer Evolution, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tim MachauerDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniele BucciWerner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.
Pooja SantSingle-Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9301-3211
Jun-Hoe LeeQuantitative Biology Center (QBiC), Eberhard Karls University Tübingen, Tübingen, Germany.ORCID 0000-0002-6331-3472
Jonas RöslerApplied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
Sven W MeckelmannApplied Analytical Chemistry, University of Duisburg-Essen, Essen, Germany.
Johannes SchreckInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Sue MurrayIonis Pharmaceuticals, Carlsbad, CA, USA.
M Celeste SimonAbramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9106-447X
Sven NahnsenCluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.ORCID 0000-0002-4375-0691
Almut SchulzeDivision of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8199-6422
Ping-Chih HoDepartment of Oncology, University of Lausanne, Epalinges, Switzerland.ORCID 0000-0003-3078-3774
Manfred JugoldCore Facility Small Animal Imaging, German Cancer Research Center Heidelberg, Heidelberg, Germany.
Kai BreuhahnInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Jan-Philipp MallmSingle-Cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-7059-4030
Peter SchirmacherInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
Susanne RothM3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Nuh RahbariDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Darjus F TschaharganehInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-2369-5138
Stephanie RoesslerInstitute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-5333-5942
Benjamin GoeppertInstitute of Pathology, RKH Hospital, Ludwigsburg, Germany.
Bertram BengschDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-2552-740X
Geoffroy AndrieuxInstitute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-5389-9481
Melanie BoerriesInstitute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3670-0602
Nisar P MalekM3-Research Center for Malignome, Metabolome and Microbiome, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, Faculty of Medicine, University of Tübingen, Tübingen, Germany.ORCID 0000-0002-9916-4608
Marco PrinzInstitute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-0349-1955
Achim WeberDepartment of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland.ORCID 0000-0003-0073-3637
Robert ZeiserDepartment of Hematology and Oncology, Freiburg University Medical Centre, Freiburg, Germany.ORCID 0000-0001-6565-3393
Pablo TamayoCenter for Novel Therapeutics and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
Peter BronsertCore Facility for Histopathology and Digital Pathology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-8558-0347
Konrad KurowskiCore Facility for Histopathology and Digital Pathology, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0009-0009-0448-7999
Robert ThimmeDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-1417-4135
Detian YuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID 0000-0003-1855-4768
Rafael CarreteroDKFZ-Bayer Immunotherapeutic Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty at Heinrich-Heine-University, Düsseldorf, Germany.ORCID 0000-0002-6288-8821
Roser PinyolLiver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0002-0288-6314
Felix J HartmannSystems Immunology and Single-Cell Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4174-2276
Michael KarinCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-2758-6473
Alpaslan TasdoganDepartment of Dermatology, University Hospital Essen, Essen, Germany.ORCID 0000-0003-2543-852X
Christoph TrautweinWerner Siemens Imaging Center (WSIC), Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tübingen, Tübingen, Germany.ORCID 0000-0003-4672-6395
Moritz MallDivision of Cell Fate Engineering and Disease Modeling, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID 0000-0002-1278-2594
Maike HofmannDepartment of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-8410-8833
Josep M LlovetLiver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Dirk HallerChair of Nutrition and Immunology, Technische Universität München, Freising, Germany. dirk.haller@tum.de.ORCID 0000-0002-6977-4085
Randal J KaufmanCenter for Metabolic and Liver Disease, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. rkaufman@sbpdiscovery.org.ORCID 0000-0003-4277-316X
Mathias HeikenwälderDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.heikenwaelder@dkfz-heidelberg.de.ORCID 0000-0002-3135-2274
Funding
Metabolic Tumor Suppressors in Renal Cancer: Unprecedented Roles in Disease ProgressionR35CA220483 · NCI · UNIVERSITY OF PENNSYLVANIA · PI M. CELESTE SIMON · 2017 to 2026
$9.4MRole of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Karin · 2024 to 2026
$9.2MHepatic stellate cells in NASH fibrosis and HCCR01DK128289 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT L. FRIEDMAN · 2021 to 2026
$2.6MDeterminants of immunotherapy response in NASH-Hepatocellular carcinomaR01CA273932 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JOSEP M LLOVET · 2023 to 2026
$2.0MDeutsche ForschungsgemeinschaftGerrman Federal Ministry of Education and ResearchHI-TRON, by Cluster of Excellence iFITNCI NIH HHS P01 CA281819NCI NIH HHS R01 CA273932NCI NIH HHS R35 CA220483NIDDK NIH HHS R01 DK128289
Abstract
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies
Indexed as
Activating Transcription Factor 6Carcinoma, HepatocellularImmunologic SurveillanceLiver NeoplasmsAnimalsCarcinogenesisCell ProliferationEndoplasmic Reticulum StressFemaleGlycolysisHepatocytesHumansImmune Checkpoint InhibitorsImmunotherapyMaleMiceActivating Transcription Factor 6ATF6 protein, humanAtf6 protein, mouseImmune Checkpoint Inhibitors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.