Evidence map›Paper›PMID 41639445›Full record

ArticleNature2026

A pore-forming antiphage defence is activated by oligomeric phage proteins.

Pramalkumar H Patel, Matthew R McCarthy, Véronique L Taylor, Gregory B Cole, Chi Zhang, Matthew M Edghill, Landon J Getz, Beatrice C M Fung, Trevor F Moraes, Alan R Davidson and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pramalkumar H PatelDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-6400-3081
Matthew R McCarthyDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0005-2878-6353
Véronique L TaylorDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0470-9346
Gregory B ColeDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Chi ZhangDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Matthew M EdghillDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0009-0004-4905-5747
Landon J GetzDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3841-1062
Beatrice C M FungDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Trevor F MoraesDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9883-6145
Alan R DavidsonDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Michael J NorrisDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada. michael.norris@utoronto.ca.ORCID 0000-0002-8325-5257
Karen L MaxwellDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada. karen.maxwell@utoronto.ca.ORCID 0000-0002-0211-5480

Funding

Canadian Institute for Health Research Project grantCareer Transition Award granted by the Emerging & Pandemic Infections Consortium at the University of TorontoNatural Sciences and Engineering Research Council of Canada
6 · The paper itself

Abstract

Bacteria have evolved a wide array of defence systems to combat phage infection, many of which rely on complex signalling systems and large protein complexes to function

Indexed as

BacteriaBacteriophagesProphagesProtein MultimerizationViral ProteinsVirus AssemblyEndodeoxyribonucleasesModels, MolecularVirionEndodeoxyribonucleasesterminaseViral Proteins

Identifiers

PMID41639445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.