Evidence map›Paper›PMID 41639431›Full record

ArticleAnalytical and bioanalytical chemistry2026

DNA sandwich nanozyme-based colorimetric and photothermal biosensor for high-efficiency detection of fusion genes.

Xiaotao He, Jun Chen, Wandi Hu, Lijie Lin, Shiqi Hu, Erhu Xiong, Danqing Lu

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaotao He *School of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China.
Jun Chen *The Oncology Department, Xiangtan Central Hospital, Xiangtan, 411100, China.
Wandi HuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China.
Lijie LinSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China.
Shiqi HuThe Oncology Department, Xiangtan Central Hospital, Xiangtan, 411100, China. 825323630@qq.com.
Erhu XiongKey Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China. xiongerhu2008@163.com.ORCID http://orcid.org/0000-0002-9085-1858
Danqing LuSchool of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha, 410004, China. danqinglu@csuft.edu.cn.

Funding

National Natural Science Foundation for Yong Scientists of China 22004132Provincial Key Research and Development Plan in Hunan 2020NK2019
6 · The paper itself

Abstract

Fusion genes are a series of typical tumor biomarkers that can induce dysregulated gene expression and generate oncogenic proteins, both of which contribute to malignant transformation. Consequently, their detection is crucial for early cancer diagnosis, treatment selection, and prognostic evaluation. However, the existing fusion gene detection techniques remain constrained by time-consuming protocols, labor-intensive sample processing, and dependence on sophisticated instrumentation. To overcome these challenges, we present a rapid and portable photothermal biosensing platform utilizing DNA sandwich nanozymes (DSNs). The DSN integrates dual functionalities: a highly specific recognition probe for the BCR-ABL fusion gene, and a peroxidase-mimetic nanozyme that catalyzes the 3,3',5,5'-tetramethylbenzidine (TMB)-H

Indexed as

Biosensing TechniquesColorimetryDNA, CatalyticFusion Proteins, bcr-ablBenzidinesHumansHydrogen PeroxideLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLimit of Detection3,3',5,5'-tetramethylbenzidineBenzidinesDNA, CatalyticFusion Proteins, bcr-ablHydrogen PeroxideColorimetric assayDNA sandwich nanozymeFusion genesPhotothermal biosensorTMB-H2O2 system

Identifiers

PMID41639431

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.