Evidence map›Paper›PMID 41639426›Full record

ArticleExperimental & molecular medicine2026

TFEB, FOXO3 and TLR4 in resveratrol-induced autophagy in a mucopolysaccharidosis IIIB mouse model.

Estera Rintz, Magdalena Podlacha, Lidia Gaffke, Grażyna Jerzemowska, Zuzanna Cyske, Karolina Pierzynowska, Grzegorz Węgrzyn

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in Therapies for Mucopolysaccharidoses.Current issues in molecular biology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Estera RintzDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland. estera.rintz@ug.edu.pl.ORCID http://orcid.org/0000-0003-4941-766X
Magdalena PodlachaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Lidia GaffkeDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Grażyna JerzemowskaDepartment of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Zuzanna CyskeDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Karolina PierzynowskaDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Grzegorz WęgrzynDepartment of Molecular Biology, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.

Funding

Narodowe Centrum Nauki (National Science Centre) 2019/35/N/NZ2/00505
6 · The paper itself

Abstract

Mucopolysaccharidosis (MPS) type IIIB is the progressive degeneration of the central nervous system. Resveratrol is proposed as a potential therapeutic molecule as a drug reducing inflammation and for improving behavior of MPS mice. Here we investigated autophagy in correlation with immune response in an MPS IIIB mouse model. The effects of resveratrol on mouse behavior and the levels of selected cytokines that influence the inflammation were assessed. The study was performed on both male and female mice treated or not with resveratrol. The results of behavioral, molecular and biochemical experiments confirmed that autophagy and immune response are disturbed in MPS IIIB mice. A correlation between behavioral disturbances and levels of heparan sulfate and TLR4 could be observed. The FOXO3 transcription factor was identified as one of the key factors in the resveratrol-mediated stimulation of the autophagy process in the MPS IIIB mouse model, though it was not the sole pathway induced by this compound. We conclude that resveratrol can modulate the degradation of glycosaminoglycans and also may contribute to the reduction of inflammation and the normalization of animal behavior in the MPS IIIB model.

Indexed as

AutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsForkhead Box Protein O3Mucopolysaccharidosis IIIStilbenesToll-Like Receptor 4AnimalsCytokinesDisease Models, AnimalFemaleMaleMiceResveratrolBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCytokinesForkhead Box Protein O3FoxO3 protein, mouseResveratrolStilbenesTcfeb protein, mouseTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID41639426
PMCPMC12992813

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.