Evidence map›Paper›PMID 41639370›Full record

Trial reportJournal of general internal medicine2026

Time to Follow-Up Colonoscopy After Positive Fecal Immunochemical Test with Centralized Patient Navigation: A Randomized Clinical Trial.

Anisha P Ganguly, Meghan C O'Leary, Seth D Crockett, Renée M Ferrari, Connor M Randolph, Lindsay R Stradtman, Alexis A Moore, Kevin Su, Xianming Tan, Alison T Brenner and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04406714 (Scaling Colorectal Cancer Screening Through Outreach, Referral, and Engagement), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04406714 nacompletednot on this map

Scaling Colorectal Cancer Screening Through Outreach, Referral, and Engagement (SCORE): A State-Level Program to Reduce Colorectal Cancer Burden in Vulnerable Populations

TypeinterventionalSponsorUNC Lineberger Comprehensive Cancer CenterRan2020 to 2024Enrolled4,318ConditionsColorectal CancerArmsTrial Mailed FIT Intervention - Age Group 50-75, Sub-Study Mailed FIT Intervention Enhanced Envelope - Age Group 45-49, Sub-Study Mailed FIT Active Comparator Plain Envelope - Age Group 45-49
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anisha P Ganguly *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Anisha_ganguly@med.unc.edu.ORCID 0000-0002-5304-3739
Meghan C O'Leary *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Seth D CrockettDivision of Gastroenterology and Hepatology, Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
Renée M FerrariLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Connor M RandolphLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lindsay R StradtmanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexis A MooreLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin SuLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xianming TanLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alison T Brenner *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Daniel S Reuland *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Scaling Colorectal Cancer Screening Through Outreach, Referral, and Engagement (SCORE): A State-Level Program to Reduce Colorectal Cancer Burden in Vulnerable PopulationsUH3CA233251 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REULAND, DANIEL S. · 2019 to 2023
$4.4M
Scaling Colorectal Cancer Screening Through Outreach, Referral, and Engagement (SCORE): A State-Level Program to Reduce Colorectal Cancer Burden in Vulnerable PopulationsUG3CA233251 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI REULAND, DANIEL S. · 2018 to 2018
$763k
NCI NIH HHS 5UH3CA233251NCI NIH HHS UG3 CA233251NCI NIH HHS UG3CA233251NCI NIH HHS UH3 CA233251
6 · The paper itself

Abstract

backgroundPatients in federally qualified health centers (FQHCs) are at risk of delay in or non-completion of follow-up colonoscopy (FC) after a positive fecal immunochemical test (FIT). Increased time to FC is associated with increased colorectal cancer (CRC) incidence, late-stage diagnosis, and mortality.

objectiveWe evaluated the impact of centralized patient navigation on completion of FC and time to FC after a positive FIT.

designThis survival analysis is a sub-analysis of a randomized clinical trial conducted in FQHC systems in North Carolina. Trial patients were randomly assigned to mailed FIT outreach and to centralized patient navigation for a positive FIT or to usual care alone.

participantsRCT participants with a positive FIT.

interventionIntervention patients with a positive FIT were offered centralized telephone-based navigation to FC, including support with procedure scheduling, bowel preparation, and social needs. Patients in the control arm received usual care. MAIN MEASURES: We compared the restricted mean time to FC in an intention-to-screen survival analysis over 1 year of follow-up. We censored by last observation date when FC was not completed. KEY

resultsAmong 4002 trial patients, 842 completed a FIT, of whom 89 (10.6%) tested positive and were included in this analysis. Forty-eight (53.9%) were female, 29 (32.6%) identified as Black, 53 (59.6%) identified as White, and 53 (59.6%) had no prior CRC screening. Fifty-eight (65.2%) were intervention patients, and 31 (34.8%) received usual care (control). Intervention patients were more likely to complete FC at 1 year than control patients (69.0% vs 38.7%, p = 0.006). The difference in mean time to FC between the arms was 80.4 days (95% CI 13.6-147.2, p = 0.018). As-screened sensitivity analyses showed that the difference in time to FC increased further with increasing levels of engagement with navigation.

conclusionsCentralized patient navigation significantly increased FC completion and reduced the mean time to FC after a positive FIT among FQHC patients. Patient navigation is an important intervention to support the timely diagnostic resolution of positive CRC screening in under-resourced settings.

trial registrationClinicalTrials.gov Identifier: NCT04406714.

Indexed as

ColonoscopyColorectal NeoplasmsEarly Detection of CancerOccult BloodPatient NavigationAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNorth CarolinaTime Factorscolorectal neoplasmspatient navigationsafety-net providersSurvival analysis

Identifiers

PMID41639370
PMCPMC13007977

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.