Evidence map›Paper›PMID 41639366›Full record

ArticleGeroScience2026

Age-related changes in proprioception are of limited size, outcome-dependent and task-dependent.

Stien Van De Plas, Jean-Jacques Orban de Xivry

Registry-linked trialAbstract read
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07367711 (Multifaced Approach of Assessing Upper Extremity Proprioception in Breast Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07367711 not yet recruitingnot on this map

Multifaced Approach of Assessing Upper Extremity Proprioception in Breast Cancer Patients With Chemotherapy-Induced Peripheral Neuropathy

TypeobservationalSponsorKU LeuvenRan2026 to 2027Enrolled145ConditionsCIPN - Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy in Breast CancerArmsQuestionnaire - Edinburgh Handedness Assessment, Questionnaire - QuickDash, Questionnaire - EORTC QLQ-CIPN20, Questionnaire - Brief Pain Inventory (BPI), Questionnaire - Multidimensional Fatigue Inventory (MFI-20)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stien Van De PlasDepartement of Movement Sciences, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-3802-8562
Jean-Jacques Orban de XivryDepartement of Movement Sciences, KU Leuven, Leuven, Belgium. jj.orban@kuleuven.be.ORCID http://orcid.org/0000-0002-4603-7939

Funding

Fonds Wetenschappelijk Onderzoek G001724N
6 · The paper itself

Abstract

Our ability to sense the position and movement of our limbs is essential for all activities of daily living. This ability arises from the signal sent by muscle spindles to the brain. While there is clear evidence for age-related changes in the quantity of muscle spindles and in their sensitivity, behavioral assessment of age-related changes in position sense have produced mixed findings even though it is taken as textbook knowledge that proprioception declines with age. Yet, study results are difficult to compare since there is no golden standard for assessment of proprioception. Therefore, we measured upper limb proprioception across several standard proprioceptive tasks together with key factors that could influence behavioral results such as touch, motor function, and cognition in 37 young (19-32 years old) and 35 older (53-71 years old) adults. We tested age-related differences in behavioral outcomes and their associations across tasks. Our results showed that age-related effects were variable, ranging from tasks where older participants performed better to tasks where they exhibit large age-related declines. Age-related declines in position sense are outcome-dependent, sometimes requiring large samples to detect small effects. The results were confirmed by meta-analysis based on data from hundreds of participants tested in our laboratory on the exact same tasks. Associations between outcome variables across or within proprioceptive tasks were overall negligible to weak. In conclusion, age-related changes in proprioception are limited in size, task- and outcome-dependent, and current tasks used to assess proprioception do not provide consistent evidence of age-related impairment in upper limb proprioception.

Indexed as

AgingProprioceptionAdultAgedFemaleHumansMaleMiddle AgedUpper ExtremityYoung AdultAgingMultisensory integrationProprioceptionRecalibrationTouch

Identifiers

PMID41639366
PMCPMC13638832

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.