Evidence map›Paper›PMID 41639348›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Gambogic acid ameliorates hepatocellular carcinoma by inhibiting oxidative stress via Nrf2-pSmad2C/2L pathway.

Liying Mao, Gaoyang Zhao, Yunyun Zhao, Xinyu Liu, Xiunian Shi, Yingying Xu, Yuqing Chen, Jingqi Zhou, Yihan Li, Yan Yang and 1 more

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liying Mao *School of Nursing, Anhui Medical University, Hefei, 230032, China.
Gaoyang Zhao *School of Nursing, Anhui Medical University, Hefei, 230032, China.
Yunyun ZhaoSchool of Nursing, Anhui Medical University, Hefei, 230032, China.
Xinyu LiuSchool of Nursing, Anhui Medical University, Hefei, 230032, China.
Xiunian ShiZhaoke Pharmaceutical (Hefei) Co., Ltd., Hefei, China.
Yingying XuSchool of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Yuqing ChenSchool of Pharmacy, Anhui Medical University, Hefei, 230032, China.
Jingqi ZhouSchool of Nursing, Anhui Medical University, Hefei, 230032, China.
Yihan LiSchool of Nursing, Anhui Medical University, Hefei, 230032, China.
Yan YangSchool of Pharmacy, Anhui Medical University, Hefei, 230032, China. yangyan@ahmu.edu.cn.
Yongfang GongSchool of Nursing, Anhui Medical University, Hefei, 230032, China. gongyongfang@ahmu.edu.cn.

Funding

Anhui Provincial Natural Science Foundation no. 2408085QH269the National Natural Science Foundation of China no. 82404966the Research Fund of Anhui Institute of translational medicine no. 2023zhyx-C16the University Natural Science Research Project of Anhui Province no. 2022AH050714
6 · The paper itself

Abstract

Gambogic acid (GA), a natural active ingredient extracted from gamboge resin, has traditionally been utilized for liver-related diseases. Prior investigations have confirmed that GA holds remarkable efficacy in mitigating inflammatory response through the Nrf2 signaling pathway; also, Nrf2 acts synergistically with TGF-β

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNF-E2-Related Factor 2Oxidative StressSmad2 ProteinXanthonesAnimalsCell MovementDiethylnitrosamineHep G2 CellsHumansMaleMiceSignal TransductionDiethylnitrosaminegambogic acidNFE2L2 protein, humanNF-E2-Related Factor 2Smad2 ProteinSMAD2 protein, humanXanthonesGAHCCNrf2/AREspSmad2C/pSmad2L

Identifiers

PMID41639348

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.