Evidence map›Paper›PMID 41639310›Full record

ArticleJournal of computer-aided molecular design2026

Pistagremic acid from Pistacia integerrima as a natural multi-target candidate tackling crucial enzymes involved in Alzheimer's disease.

Muhammad Asim, Marryum, Saima Naz, Abdur Rauf, Nouman Aslam, Umer Rashid, Zuneera Akram, Walaa F Alsanie, Abdulhakeem S Alamri, Amal F Alshammary and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Muhammad AsimInstitute of Biotechnology & Microbiology, Bacha Khan University, Charsadda, KP, Pakistan.
MarryumDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Saima NazInstitute of Biotechnology & Microbiology, Bacha Khan University, Charsadda, KP, Pakistan. saima_khan201164@yahoo.com.
Abdur RaufDepartment of Chemistry, University of Swabi, Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan.
Nouman AslamDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan.
Umer RashidDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan. umerrashid@cuiatd.edu.pk.
Zuneera AkramDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
Walaa F AlsanieDepartment of Clinical Laboratory Sciences, The faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Abdulhakeem S AlamriDepartment of Clinical Laboratory Sciences, The faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia.
Amal F AlshammaryDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Giovanni RibaudoDepartment of Molecular and Translational Medicine, Università di Brescia, Brescia, Italy. giovanni.ribaudo@unibs.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products have crucial relevance both in traditional medicine as well as in modern drug discovery. Indeed, they inspire currently developed drugs, emphasizing the importance of biodiversity and sustainability. Alzheimer's disease (AD), a complex neurodegenerative disorder marked by amyloid plaques and neurofibrillary tangles, involves dysregulation of molecular pathways including increased cholinesterases and monoamine oxidase-B (MAO-B) activities, with enzyme inhibition remaining a key therapeutic strategy. This study investigates pistagremic acid, a triterpene from Pistacia chinensis subsp. integerrima and its inhibitory effects on such crucial enzymes implicated in AD. The compound showed moderate inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro with selectivity for AChE, while a potent inhibition of MAO-B was noted, indicating potential neuroprotective effects by reducing oxidative stress. Molecular docking showed interactions with key enzyme residues, and off targets were studied with a ligand-based approach. The findings support its multi-target therapeutic potential, but also prompt future studies exploring selectivity profile.

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsMonoamine Oxidase InhibitorsNeuroprotective AgentsPistaciaTriterpenesAcetylcholinesteraseButyrylcholinesteraseHumansMolecular Docking SimulationMonoamine OxidaseAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsMonoamine OxidaseMonoamine Oxidase InhibitorsNeuroprotective AgentsTriterpenesAlzheimer’s diseaseMolecular dockingNeuroprotectionPistagremic acidPolypharmacology

Identifiers

PMID41639310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.