ArticleScientific reports2026
Determination of cardiac output, shunt-fraction, and active circulatory volume in children with hypoplastic left heart syndrome after the Norwood procedure with RV to PA-shunt.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Congenital heart defects - diagnosis and treatment.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Management of neonates with hypoplastic left heart syndrome following the Norwood procedure seeks to optimize systemic oxygen delivery while maintaining an appropriate distribution between systemic and pulmonary blood flow. The objective of this study was to quantify actively circulating blood volume, total cardiac output, the pulmonary-to-systemic blood flow ratio (Qp/Qs), and vascular resistance indices at fractions of inspired oxygen (FiO2) of 0.21, 0.5, and 0.9 during the early postoperative period. Measurements were obtained in 16 neonates using an ultrasound dilution technique that determines hemodynamic variables from changes in blood ultrasound velocity following injection of isotonic saline (COstatus, Transonic Systems Inc.). An increase in the Qp/Qs ratio was observed with rising FiO2, which was associated with a reduction in systemic blood flow, while pulmonary blood flow remained statistically unchanged across the FiO2 levels studied. This pattern is consistent with the interpretation that pulmonary blood flow in this setting is mainly influenced by the mechanical properties of the right ventricle to pulmonary artery shunt rather than by FiO2 mediated changes in pulmonary vascular tone. Actively circulating volume index was reduced at baseline and decreased further with increasing FiO2 accompanied by an increase in systemic vascular resistance. These findings indicate that the early postoperative hemodynamics in neonates after the Norwood procedure are more responsive to alterations in systemic circulation than to modulation of pulmonary vascular tone. Therapeutic strategies targeting augmentation of circulating blood volume and reduction of systemic afterload warrant further investigation as potential approaches to optimize postoperative management in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.