SynthesisLangenbeck's archives of surgery2026
Outcomes following out-of-hours acute appendectomy: a systematic review and meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
purposeAppendicitis is one of the most common emergency diseases. Currently, it is unclear whether there are differences in performing appendectomy during in-hour (IH) versus out-of-hour (OH).
methodsA comprehensive search for studies that compared IH and OH was conducted in Web of Science, PubMed and EMBASE. Data of including studies were subjected to meta-analysis. The study was registered on PROSPERO (CRD42023467592).
resultThe result indicated that the OH group had more complicated appendicitis (OH 25.1% vs. IH 24.5%, RD = 0.02; 95% CI, 0.00 to 0.05; p = 0.04, I2 = 72%), higher level of C-reactive reaction protein (OH 44.88 ± 16.14 vs. IH 41.19 ± 16.50, MD = 12.15; 95% CI, 2.28 to 22.01; p = 0.02, I2 = 100%) and higher rate of conversion to open surgery {OH 8.0% vs. IH 7.8%, RD = 0.02; 95% CI, 0.00 to 0.03; p = 0.02, I2 = 93%. 95% Predictive interval (PI), -0.04 to 0.08}. No significant differences were observed in operative time, length of hospital stay, surgical site infection rates, readmission, reintervention, or the distribution of Clavien-Dindo grades1-2 and3-4 complications. Thirty-day mortality and overall mortality were also comparable.
conclusionOH appendectomy does not affect perioperative complications or mortality in patients with appendicitis compared to IH. These results should be interpreted cautiously due to the limited number of available studies.
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