ArticleCommunications biology2026
enGLOW 3D microscopy of the enteric nervous system in cleared human and mouse gut.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Three-dimensional modeling of sensory nerve architecture and eosinophil and mast cell interactions in eosinophilic gastrointestinal disease.Journal of leukocyte biology · 2026Article
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13 authors.
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Abstract
The enteric nervous system (ENS) is involved in many gastrointestinal (GI) disorders and our understanding of how gut morphology is disrupted remains limited due to a lack of tools to investigate tissues at the organ scale. Here we present enGLOW (enteric network Gastrointestinal Lightsheet Optical Workflow), a workflow customized for high spatial-resolution investigation of the ENS in gastrointestinal samples. We demonstrate how enGLOW can extract quantitative data in cubic centimeters of intact tissue. In a single dataset, we quantify intestinal wall metrics in autofluorescence and labeled ENS-associated cells in centimeter-long segments of tissue using three-dimensional (3D) segmentation. With virtual tissue flattening, we separate neuronal plexuses in mouse and human samples, and observe variations in mucosal morphology and labeled signal distribution in genetically modified animals. As an optimized ready-to-use workflow, enGLOW expands the gut research toolbox to enable understanding of enteric network morphology at scales that encompass functional networks.
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