Evidence map›Paper›PMID 41639250›Full record

ArticleScientific reports2026

The role of toll-like receptor 7 signaling in mice infected by severe fever with thrombocytopenia syndrome virus.

Gaeul Ham, Byungkwan Oh, Seok-Chan Park, Dongseob Tark, Jun-Gu Choi, Sang-Ik Oh, Bumseok Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gaeul HamBiosafety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Byungkwan OhBiosafety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Seok-Chan ParkBiosafety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Dongseob TarkLaboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, 820-120, Hana-Ro, Iksan, Jeollabuk-Do, 54531, Republic of Korea.
Jun-Gu ChoiForeign Animal Disease Division, Animal and Plant Quarantine Agency 177, Hyeoksin 8-Ro, Gimcheon, Gyeongsangbuk-Do, 39660, Republic of Korea.
Sang-Ik OhBiosafety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea.
Bumseok KimBiosafety Research Institute and Laboratory of Veterinary Pathology, College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-Ro, Iksan-Si, Jeollabuk-Do, 54596, Republic of Korea. bskims@jbnu.ac.kr.

Funding

National Research Foundation of Korea RS-2019-NR040075
6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a negative-sense RNA virus that can cause high fever, thrombocytopenia, and multiple-organ dysfunction. Toll-like receptor 7 (TLR7) can recognize single-stranded RNA viruses and induce type I interferons (IFNs). Although type I IFNs play a critical role in SFTSV infection, the role of TLR7 remains incompletely understood. To investigate the role of TLR7 signaling in SFTSV pathogenesis, TLR7-deficient (TLR7

Indexed as

PhlebovirusSevere Fever with Thrombocytopenia SyndromeSignal TransductionToll-Like Receptor 7AnimalsDisease Models, AnimalImidazolesMembrane GlycoproteinsMiceMice, KnockoutRNA, ViralSpleenToll-Like Receptor AgonistsViral LoadImidazolesMembrane GlycoproteinsresiquimodRNA, ViralTlr7 protein, mouseToll-Like Receptor 7Toll-Like Receptor AgonistsResiquimodSevere fever with thrombocytopenia syndromeToll-like receptor 7Type I interferon

Identifiers

PMID41639250
PMCPMC12923743

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.