ArticleScientific reports2026
Exploring the toxic mechanism of cypermethrin-induced neurodegeneration diseases via network toxicology and molecular docking.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Impact of cigarette toxicants on sarcopenic obesity: An in silico network toxicology and molecular dynamics study.Tobacco induced diseases · 2026Article
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5 authors.
Funding
Abstract
Cypermethrin, a type II synthetic pyrethroid insecticide, is a pervasive environmental contaminant of growing concern owing to its ecological persistence and potential health risks. This study combined network toxicology and molecular docking to investigate the role of cypermethrin in neurodegenerative diseases. Potential targets of cypermethrin were predicted using the Similarity Ensemble Approach, SwissTargetPrediction, PharmMapper, and Comparative Toxicogenomics Database. Disease-related targets were sourced from GeneCards, the Therapeutic Target Database, and Online Mendelian Inheritance in Man. In total, 108 overlapping targets were identified. The core targets were prioritized using STRING 12.0 and Cytoscape (Version: 3.10.0), followed by functional enrichment analysis. The results indicated the significant involvement of cancer-related pathways, endocrine resistance, and PI3K-AKT signaling. Molecular docking and molecular dynamics simulations confirmed the strong affinity of cypermethrin for CREBBP, GSK3B, and ALB. These findings provide a foundation for the development of diagnostic tools for diseases linked to cypermethrin exposure, although further experimental and clinical validation is necessary.
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