Evidence map›Paper›PMID 41639121›Full record

ArticleNature communications2026

Two-step voltage-sensor activation of the human K

Mario Nappi, Damon J A Frampton, Ali S Kusay, Kaiqian Wang, S Suheda Yasarbas, Serena Pozzi, Francesco Miceli, Sara I Liin, Maurizio Taglialatela, Antonios Pantazis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mario NappiDepartment of Neuroscience, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-1243-0935
Damon J A FramptonDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Ali S KusayDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Kaiqian WangDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0002-6315-8732
S Suheda YasarbasDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0009-0002-8528-2539
Serena PozziDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Francesco MiceliDepartment of Neuroscience, University of Naples "Federico II", Naples, Italy.
Sara I LiinDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0001-8493-0114
Maurizio TaglialatelaDepartment of Neuroscience, University of Naples "Federico II", Naples, Italy. maurizio.taglialatela@unina.it.ORCID 0000-0002-8202-0560
Antonios PantazisDivision of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. antonios.pantazis@liu.se.ORCID 0000-0002-6467-1327

Funding

Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) WCMM-LiU start-upVetenskapsrådet (Swedish Research Council) 2021-01885Vetenskapsrådet (Swedish Research Council) 2022-00574
6 · The paper itself

Abstract

KCNQ4-encoded K

Indexed as

DeafnessKCNQ Potassium ChannelsMutationAnimalsHEK293 CellsHumansIon Channel GatingKineticsMolecular Dynamics SimulationPatch-Clamp TechniquesProtein DomainsKCNQ4 protein, humanKCNQ Potassium Channels

Identifiers

PMID41639121
PMCPMC12982505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.