Evidence map›Paper›PMID 41639086›Full record

ArticleNature communications2026

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4

Victoria Stavrou, Myah Ali, Nancy Gudgeon, Emma L Bishop, Taylor Fulton-Ward, Bethany Turley, Silke Heising, Sally H Mohamed, Sofia Hain, Lorna George and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Victoria StavrouDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0009-0009-3245-4967
Myah AliDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Nancy GudgeonDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-0396-5241
Emma L BishopDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Taylor Fulton-WardDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Bethany TurleyDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Silke HeisingDepartment of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-7011-8333
Sally H MohamedDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Sofia HainDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-7993-2828
Lorna GeorgeDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Minghao DengDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Jack McCowanCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-5121-4549
Lozan SheriffDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-8364-9080
Scott P DaviesDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-6899-1339
Bryan MarzulloDepartment of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0002-1874-6906
Daniel A TennantDepartment of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Craig L DoigDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.ORCID 0000-0001-9694-4230
David A BendingDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0003-0071-1163
Ed W RobertsCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-8229-1715
Gareth G LaveryDepartment of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Rebecca A DrummondDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0001-5424-7074
Sarah DimeloeDepartment of Immunology and Immunotherapy, College of Medicine and Health, University of Birmingham, Birmingham, UK. s.k.dimeloe@bham.ac.uk.ORCID 0000-0002-4598-6518

Funding

RCUK | Medical Research Council (MRC) MR/V011588/1
6 · The paper itself

Abstract

T cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation. It's phosphorylation to NADP/H regulates reactive oxygen species (ROS) abundance. NAD/H levels increase upon T cell activation, but synthesis pathways and implications are not fully characterised. Here, we interrogate the role of the NAD/H-synthesis enzyme nicotinamide riboside kinase 1 (NRK1), the expression of which increases upon stimulation of both human and murine CD4

Indexed as

CD4-Positive T-LymphocytesCytoplasmInflammationNADPhosphotransferases (Alcohol Group Acceptor)AnimalsCell SurvivalGlycolysisHumansLymphocyte ActivationMiceMice, Inbred C57BLNADPNFATC Transcription FactorsReactive Oxygen SpeciesNADNADPNFATC Transcription FactorsPhosphotransferases (Alcohol Group Acceptor)Reactive Oxygen Species

Identifiers

PMID41639086
PMCPMC12979809

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.