High-power pulsed electrochemiluminescence for optogenetic manipulation of Drosophila larval behaviour.

Chang-Ki Moon, Matthias König, Ranjini Sircar, Julian F Butscher, Ronald Alle, Klaus Meerholz, Stefan R Pulver, Malte C Gather

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Article in Light, science & applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chang-Ki MoonHumboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany. changki.moon@uni-koeln.de.

Matthias KönigHumboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany.

Ranjini SircarHumboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany.

Julian F ButscherHumboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany.

Ronald AlleInstitute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany.

Klaus MeerholzInstitute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany.

Stefan R PulverSchool of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, St Andrews, UK.

Malte C GatherHumboldt Centre for Nano- and Biophotonics, Institute for Light and Matter, Department of Chemistry and Biochemistry, University of Cologne, Cologne, Germany. malte.gather@uni-koeln.de.ORCID http://orcid.org/0000-0002-4857-5562

Funding

Alexander von Humboldt-Stiftung (Alexander von Humboldt Foundation) Humboldt ProfessorshipEuropean Commission (EC) 101029807

6 · The paper itself

Abstract

Electrochemiluminescence (ECL) produces light through electrochemical reactions and has shown promise for various analytic applications in biomedicine. However, the use of ECL devices (ECLDs) as light sources has been limited due to insufficient light output and low operational stability. In this study, we present a high-power pulsed operation strategy for ECLDs to address these limitations and demonstrate their effectiveness in optogenetic manipulation. By applying a biphasic voltage sequence with short opposing phases, we achieve intense and efficient ECL through an exciplex-formation reaction pathway. This approach results in an exceptionally high optical power density, exceeding 100 μW mm

Identifiers

PMID41639052

DOI10.1038/s41377-025-02143-y

PMCPMC12873326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.