Evidence map›Paper›PMID 41639048›Full record

ReviewNature communications2026

Advances and challenges in non-canonical nucleic acids data storage.

Yan Wang, Yufeng Pei, Linlin Tang, Xinyu Sun, Songtao Zhou, Jie Song

Abstract readReview
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan WangSchool of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0009-2998-0413
Yufeng PeiHangzhou Institute of Medicine Chinese Academy of Sciences, Hangzhou, China. peiyufeng@him.cas.cn.ORCID http://orcid.org/0000-0002-7515-6793
Linlin TangHangzhou Institute of Medicine Chinese Academy of Sciences, Hangzhou, China.
Xinyu SunDepartment of Chemistry, University of Science and Technology of China, Hefei, Anhui, China.
Songtao ZhouHangzhou Institute of Medicine Chinese Academy of Sciences, Hangzhou, China.
Jie SongHangzhou Institute of Medicine Chinese Academy of Sciences, Hangzhou, China. songjie@him.cas.cn.ORCID http://orcid.org/0000-0002-4711-6014

Funding

National Key Research and Development Program of ChinaNational Natural Science Foundation of China (National Science Foundation of China) 22307123Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) YXD23B0301
6 · The paper itself

Abstract

Canonical nucleic acids (DNA and RNA) naturally store genetic information with high density and programmability, making them promising candidates for molecular data storage. However, their susceptibility to degradation under harsh conditions, such as extreme pH, nuclease activity, and chemical attack, limits practical applications. In contrast, non-canonical nucleic acids (ncNAs) with natural or synthetic structural modifications exhibit enhanced stability and unique functional potential. This review systematically summarizes the fundamental properties of ncNAs, evaluates their suitability for molecular data storage, and discusses how their distinctive advantages may overcome the intrinsic limitations of canonical nucleic acids while addressing challenges in next-generation storage systems.

Indexed as

DNAInformation Storage and RetrievalNucleic AcidsRNAHumansNucleic Acid ConformationDNANucleic AcidsRNA

Identifiers

PMID41639048
PMCPMC12979619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.