Evidence map›Paper›PMID 41638947›Full record

ReviewTrends in neurosciences2026

Dopamine's secret agent: serotonin.

Andrew J Miller-Hansen, Talia N Lerner

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew J Miller-HansenDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Departments of Neurology and Physiology, School of Medicine, University of California-San Francisco, San Francisco, CA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
Talia N LernerDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Electronic address: talia.lerner@northwestern.edu.

Funding

Integration of Feeding Time and Glucose Metabolism by the Circadian Gene NetworkR01DK090625 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BASS, JOSEPH, LERNER, TALIA NEWCOMBE · 2011 to 2025
$6.9M
Plasticity and Function of Dopamine Circuits Regulating the Transition to HabitR01MH125885 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jones G Parker · 2023 to 2026
$2.0M
NIDDK NIH HHS R01 DK090625NIMH NIH HHS R01 MH125885
6 · The paper itself

Abstract

Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent-instituting a high-pass filter on striatal 'direct pathway' transmission-and does not require dopamine receptors. Rather, dopamine upregulates serotonin, activating presynaptic 5HT

Indexed as

DopamineSerotoninAnimalsCorpus Striatumgamma-Aminobutyric AcidHumansSynaptic TransmissionDopaminegamma-Aminobutyric AcidSerotoninbasal gangliadirect pathwaymotor controlneuromodulatory interactionsstriatumsubstantia nigra

Identifiers

PMID41638947
PMCPMC12880613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.