ArticleACS biomaterials science & engineering2026
Enhancing Biocompatibility and Biophysical Properties of Three-Dimensional Collagen Scaffolds Using Nonthermal Plasma Treatment.
Article in ACS biomaterials science & engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
Collagen-glycosaminoglycan (CG) scaffolds are extensively utilized in tissue engineering for their excellent biocompatibility and low immunogenicity; however, their poor mechanical stiffness typically requires further physical or chemical modifications to enhance their structural integrity for clinical applications. We investigate the effects of nonthermal plasma (NTP) treatment; an emerging technology commonly used in the biomedical field for surface modifications, sterilization, and wound healing. A comprehensive analysis is conducted to evaluate the surface characteristics, biophysical properties, and biocompatibility of the 3D CG scaffolds treated with NTP for 2 and 5 min, compared with untreated controls. Histological and SEM analyses demonstrated thickening of the scaffold pore struts and an increase in porosity, while Energy Dispersive X-ray Spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) confirmed that the native chemical composition of the scaffolds remained intact and unchanged following NTP exposure. Post-treatment, the scaffolds exhibited increased hydrophilicity demonstrated by a reduced contact angle. Mechanical testing showed significant improvements in the scaffold's compression modulus, with increases of approximately 16.7% and 14.5% for 2 min and 5 min treatments, respectively (
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