ReviewEuropean respiratory review : an official journal of the European Respiratory Society2026
Neuroplasticity and neuroimmune interactions with type 2 inflammation in asthma.
Review in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Impact of Chronic Stress and Trauma on Asthma Pathophysiology and Outcomes.Current allergy and asthma reports · 2026Review
- The Role of the Nervous System in Lung Disease.Current neurology and neuroscience reports · 2026Review
- Neuroimmune Regulation in Posttraumatic Bone Repair: From Inflammatory Transition to Neurovascular Coupling and Functional Recovery.Journal of cellular physiology · 2026Review
- Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026Review
- Controlling Neuroplasticity Across Scales: Constrained Serotonergic Agonists, Neuroplastogens, and Adaptive Neuromodulation.ACS medicinal chemistry letters · 2026Article
- A Comprehensive Review of Natural Products Against Allergic Rhinitis and Asthma: From Sensitization to Chronic Remodeling.International journal of molecular sciences · 2026Review
- Repairing the lung: from single cells and tissue organisation to regenerative therapy - highlights of the Lung Science Conference 2025.European respiratory review : an official journal of the European Respiratory Society · 2026Article
- Neuroimmune regulation of post-traumatic bone regeneration: focus on inflammatory switching and functional recovery.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lungs are innervated by both afferent and efferent nerve fibres that regulate key respiratory functions, including the cough reflex, airway tone, mucus secretion, and the detection of mechanical and chemical stimuli. In asthma, airway hyperresponsiveness and inflammation are, in part, modulated by the nervous system. Recent findings have identified neuroplasticity as a pathological feature of severe asthma, suggesting that altered neural remodelling contributes to disease symptoms. Additionally, growing evidence highlights bidirectional interactions between the airway nervous system and local immune cells, which play a crucial role in modulating each other's activity. In this review, we explore the emerging roles of airway neuroplasticity and neuroimmune interactions in the development of type 2 inflammation in asthma. We focus on the involvement of neuropeptides and cytokines in mediating this bidirectional crosstalk, aiming to elucidate the mechanistic link between neural remodelling and immune activation and to identify novel targets for pharmacological intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.