Evidence map›Paper›PMID 41638740›Full record

SynthesisBMJ open2026

Clinical indication-based diagnostic reference levels in CT: a systematic review.

Abdul Alim, Sook Sam Leong, Ann Erynna Lema Thomas Sudin, Diryaz Hamad Awla

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abdul AlimCenter for Medical Imaging Studies, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.ORCID http://orcid.org/0009-0004-3465-1925
Sook Sam LeongCenter for Medical Imaging Studies, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia sam_leong10284@icloud.com.ORCID http://orcid.org/0000-0001-9225-1461
Ann Erynna Lema Thomas SudinCenter for Medical Imaging Studies, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.ORCID http://orcid.org/0000-0002-5365-6666
Diryaz Hamad AwlaRadiology, Hawler Medical University College of Medicine, Erbil, Kurdistan Region, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA growing number of national diagnostic reference levels based on clinical indications (NDRL

designSystematic review.

settingA systematic literature search was conducted in PubMed, Web of Science and Scopus from 1996 to 24 august 2025. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis framework was followed to report the study selection process in this review. Joanna Briggs Institute's critical appraisal tools were used to evaluate the articles critically.

participantsAdult patients undergoing CT scans for various clinical indications.

interventionClinical indication-based CT protocols with reported NDRL PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcomes were NDRL

resultA total of 4146 articles were identified. 410 full texts were examined and 11 studies were included in the systematic review. 25 clinical indications across seven anatomical regions were identified across 11 included studies. The NDRL

conclusionSeveral factors contribute to dose discrepancies for the same clinical indications in CT imaging, including kilovolt peak and milliampere-second, scan length, number of phases, patient size, reconstruction algorithm, CT scanner age and specifications, underscoring the need for standardised and optimised CT protocols. This review highlighted several challenges, which emphasise the importance of international organisations to standardise the development of NDRL PROSPERO REGISTRATION NUMBER: CRD42024603574.

Indexed as

Diagnostic Reference LevelsTomography, X-Ray ComputedHumansRadiation DosageComputed tomographyDiagnostic ImagingRADIOLOGY & IMAGING

Identifiers

PMID41638740
PMCPMC12878312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.