Evidence map›Paper›PMID 41638656›Full record

ArticleEndocrine journal2026

Associations among serum soluble T-cadherin levels, serum adiponectin levels, and metabolic risk factors in a Japanese population undergoing medical health checkups.

Masahito Iioka, Shiro Fukuda, Ryohei Mineo, Tomonori Okita, Keitaro Kawada, Emi Horitani, Yoshinari Obata, Hirofumi Nagao, Yuya Fujishima, Jun Murai and 5 more

Abstract read
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In one paragraph

Article in Endocrine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masahito IiokaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Shiro FukudaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0003-0712-7154
Ryohei MineoDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Tomonori OkitaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Keitaro KawadaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0003-4976-2121
Emi HoritaniDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yoshinari ObataDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0002-3443-3635
Hirofumi NagaoDepartment of Metabolism and Atherosclerosis, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0009-0001-1261-4160
Yuya FujishimaDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0003-0028-1757
Jun MuraiDepartment of Diabetes and Endocrinology, Kawasaki Hospital, Hyogo, Japan.
Morihiro MatsudaDepartment of Diabetes and Endocrinology, Kawasaki Hospital, Hyogo, Japan.
Tadashi NakamuraDepartment of Diabetes and Endocrinology, Kawasaki Hospital, Hyogo, Japan.
Tohru FunahashiDepartment of Diabetes and Endocrinology, Kawasaki Hospital, Hyogo, Japan.
Hitoshi NishizawaDepartment of Metabolism and Atherosclerosis, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Iichiro ShimomuraDepartment of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka, Japan.ORCID http://orcid.org/0000-0002-0851-9603

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble T-cadherin (sT-cad), which is a circulating form of membrane T-cadherin, is present in human serum. We examined the relationships among sT-cad levels, adiponectin (APN) levels, and the number of metabolic risk factors in individuals undergoing medical health checkups. A total of 1,144 Japanese individuals (811 males and 333 females, average age: 56.3 ± 9.9 years in males and 53.7 ± 10.1 years in females) were analyzed. Serum levels of sT-cad and APN were measured by enzyme-linked immunosorbent assay (ELISA). Associations of sT-cad and APN levels with the number of metabolic risk factors (abdominal obesity, diabetes, hypertension, and dyslipidemia) were evaluated. Serum 130-kDa sT-cad levels were significantly lower in males than in females, and were positively correlated with APN levels. Individuals with low APN levels exhibited more metabolic risk factors. Notably, among males with high APN levels, those with low 130-kDa sT-cad levels had a greater number of metabolic risk factors than those with high 130-kDa sT-cad levels. Serum 130-kDa sT-cad levels were significantly correlated with APN levels in individuals undergoing medical health checkups. Even among males with high APN levels, low sT-cad levels were indicative of the presence of more metabolic risk factors.

Indexed as

AdiponectinCadherinsDiabetes MellitusMetabolic SyndromeAdultAgedDyslipidemiasEast Asian PeopleFemaleHumansHypertensionJapanMaleMiddle AgedObesity, AbdominalRisk FactorsAdiponectinADIPOQ protein, humanCadherinsH-cadherinAdiponectinHealth checkupSoluble T-cadherin

Identifiers

PMID41638656
PMCPMC13195459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.