Evidence map›Paper›PMID 41638627›Full record

ArticleBrain stimulation

Transcranial alternating current stimulation can disrupt or reestablish neural entrainment in parkinsonian motor cortex.

Harry Tran, Biswaranjan Mohanty, Noah Hjelle, Zhihe Zhao, Sangjun Lee, Adele DeNicola, Ivan Alekseichuk, Miles Wischnewski, Jing Wang, Jerrold Vitek and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Harry TranDepartment of Biomedical Engineering, University of Minnesota, 55455, MN, USA. Electronic address: htran@umn.edu.
Biswaranjan MohantyDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Noah HjelleDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Zhihe ZhaoDepartment of Biomedical Engineering, University of Minnesota, 55455, MN, USA.
Sangjun LeeDepartment of Biomedical Engineering, University of Minnesota, 55455, MN, USA.
Adele DeNicolaDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Ivan AlekseichukStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, 60611, IL, USA.
Miles WischnewskiDepartment of Experimental Psychology, University of Groningen, 9712, Netherlands.
Jing WangDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Jerrold VitekDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Luke JohnsonDepartment of Neurology, University of Minnesota, 55455, MN, USA.
Alexander OpitzDepartment of Biomedical Engineering, University of Minnesota, 55455, MN, USA. Electronic address: aopitz@umn.edu.

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Traveling Wave Transcranial Alternating Current Stimulation for the Control of Large-Scale Brain NetworksRF1MH124909 · NIMH · UNIVERSITY OF MINNESOTA · PI OPITZ, ALEXANDER · 2020 to 2020
$2.4M
NIMH NIH HHS RF1 MH124909NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS110613NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

backgroundIn Parkinson's disease, motor network electrophysiology frequently exhibits excessive beta oscillations. The cornerstone of therapeutic efficacy lies in the ability to modulate these pathological oscillations. Transcranial alternating current stimulation (tACS), a non-invasive method that applies oscillating electric fields to modulate ongoing brain activity, offers a promising approach.

objectiveThe objective of the manuscript is to investigate the dose-dependent effects of tACS on motor network cortical neurons in a Parkinson's disease model.

methodsWe recorded neuronal spike activity in the motor cortex in parkinsonian non-human primates during tACS to determine how stimulation-induced electric fields affect spike timing.

resultsStrong electric fields entrained neural activity at the stimulation frequency but altered the preferred spiking phase. Conversely, weak fields disrupted beta-band synchronization by modulating spike timing and phase preference. Frequency-matched stimulation significantly enhanced entrainment when aligned with endogenous oscillatory activity.

conclusionThus, with appropriately chosen stimulation parameters, tACS exhibits significant potential for controlling and modulating pathological oscillatory patterns that are characteristic of many neurological disorders.

Indexed as

Motor CortexNeuronsParkinsonian DisordersTranscranial Direct Current StimulationAnimalsDisease Models, AnimalMacaca mulattaMaleTreatment OutcomeMPTPParkinson's diseasePhase lockingSingle unittACS

Identifiers

PMID41638627
PMCPMC13037566

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.