Evidence map›Paper›PMID 41638524›Full record

ArticleCancer letters2026

High-throughput drug screening for targeting polyploid cancer cells with an interactive web portal.

Hsiao-Chun Chen, Li-Ju Wang, Chien-Hung Shih, Huikang Ye, Ying-Ju Lai, Jinxiong Cheng, Yuan Zhang, Yushu Ma, Tiffany Habib, Shailrajsinh H Jhala and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hsiao-Chun ChenUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA, 15260, USA.
Li-Ju WangUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Chien-Hung ShihUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Huikang YeUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Ying-Ju LaiUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Biostatistics and Health Data Science, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA, 15261, USA.
Jinxiong ChengUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA, 15260, USA.
Yuan ZhangUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Immunology, University of Pittsburgh, 5051 Centre Ave, Pittsburgh, PA, 15213, USA.
Yushu MaUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA.
Tiffany HabibUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Shailrajsinh H JhalaUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Hsi-Chun WangUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA.
Yu-Chiao ChiuUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA; Department of Biostatistics and Health Data Science, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA, 15261, USA; Division of Malignant Hematology and Medical Oncology, Department of Medicine, University of Pittsburgh, 5150 Centre Avenue, Pittsburgh, PA, 15232, USA; Computational Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA. Electronic address: YUC250@pitt.edu.
Yu-Chih ChenUPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA, 15232, USA; Department of Computational and Systems Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA, 15260, USA; Computational Biology, University of Pittsburgh, 3420 Forbes Avenue, Pittsburgh, PA, 15260, USA. Electronic address: yuc151@pitt.edu.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Project 3: Hedgehog Inhibition to Enhance Response to ICI TherapyP50CA272218 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRANCESMARY MODUGNO · 2023 to 2026
$11.0M
Enhancing AI-readiness of multi-omics data for cancer pharmacogenomicsR00CA248944 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHIU, YU-CHIAO · 2022 to 2024
$1.1M
Open science platform for cancer dependency prediction and analysis using deep learning and large language modelsR03CA305794 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yu-Chiao Chiu · 2025 to 2026
$474k
Halting Breast Cancer Metastasis by Blocking Cancer-MSC EngulfmentR21CA293424 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yu-Chih Chen · 2025 to 2026
$398k
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA272218NCI NIH HHS R00 CA248944NCI NIH HHS R03 CA305794NCI NIH HHS R21 CA293424
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug screeningInteractive web portalPolyploid giant cancer cellsSingle-cell analysis

Identifiers

PMID41638524
PMCPMC12959572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.