Evidence map›Paper›PMID 41638202›Full record

ArticleNeuron2026

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses.

Rachael E Hokenson, Kiara L Rodríguez-Acevedo, Yuncai Chen, Annabel K Short, Sara A Samrari, Brinda Devireddy, Brittany J Jensen, Julia J Winter, Christine M Gall, Kiran K Soma and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Rachael E HokensonDepartment of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
Kiara L Rodríguez-AcevedoDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yuncai ChenDepartment of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
Annabel K ShortDepartment of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
Sara A SamrariDepartment of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Brinda DevireddyDepartment of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Brittany J JensenGraduate Program in Neuroscience, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Julia J WinterDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Christine M GallDepartment of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA.
Kiran K SomaDjavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Elizabeth A HellerDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tallie Z BaramDepartment of Anatomy/Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: tallie@uci.edu.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2013 to 2023
$25.4M
Epigenetic mechanisms of sustained transcription across cocaine abstinenceR01DA052465 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2021 to 2026
$4.0M
Dynamic epigenomic landscape of opioid abuse following early-life adversityU01DA053826 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, CHRISTIE D FOWLER · 2022 to 2026
$3.4M
Epigenetic regulation of Cdk5 in cognition and emotionR01MH126027 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2023 to 2026
$2.2M
On circuit mechanisms of reward behaviors after early-life adversityRF1MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2025 to 2025
$2.1M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
On circuit mechanisms of reward behaviors after early-life adversityR01MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2023 to 2024
$1.3M
Training Program in Substance Use and Use DisordersT32DA050558 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI WOOD, MARCELO ANDRES · 2020 to 2024
$892k
NIDA NIH HHS R01 DA052465NIDA NIH HHS T32 DA050558NIDA NIH HHS U01 DA053826NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH126027NIMH NIH HHS R01 MH132680NIMH NIH HHS RF1 MH132680NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

It is increasingly recognized that acute traumatic events (e.g., mass shootings, natural disasters) can provoke enduring episodic memory deficits and generalization of trauma cues, and these are more common in women. We investigated the mechanisms and sex differences in memory vulnerability to multiple acute concurrent stresses (MACSs) in mice, focusing on the sex hormone 17β-estradiol and its receptors in the hippocampus. Surprisingly, high physiological hippocampal estradiol levels, observed in proestrus females and males, were required for MACS-induced episodic memory disruption and sensitization and generalization of stress cues. High estradiol levels were associated with permissive chromatin states in stress-vulnerable mice, while chromatin permissiveness and hippocampal estradiol were low in stress-resilient estrus females. Estrogen receptor (ER)β activation in resilient estrus females increased chromatin permissiveness and enduring vulnerability to MACSs, while ERα mediated milder stress-induced memory disruptions in males. Thus, hippocampal estradiol levels and sex modify chromatin states to enable long-lasting memory vulnerabilities to MACSs.

Indexed as

Epigenesis, GeneticEstradiolEstrogen Receptor alphaEstrogen Receptor betaEstrogensHippocampusMemorySex CharacteristicsStress, PsychologicalAnimalsFemaleMaleMiceMice, Inbred C57BLEstradiolEstrogen Receptor alphaEstrogen Receptor betaEstrogenschromatin stateepigeneticsestradiolestrogenmemoryPTSDreceptorsex differencesstresswomen's health

Identifiers

PMID41638202
PMCPMC13001641

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.