Evidence map›Paper›PMID 41638198›Full record

ArticleCell reports. Medicine2026

Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury.

Qi Liu, Borui Xue, Yongfeng Zhang, Mingze Qin, Ziqing Zhu, Zhenguo Wang, Hongyu Li, Shuanshuan Fan, Meijia Su, Shengyou Li and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Qi LiuDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Borui XueDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; 986th Hospital of Air Force, Fourth Military Medical University, Xi'an 710054, China.
Yongfeng ZhangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Department of Neurology, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710072, China.
Mingze QinDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Ziqing ZhuDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhenguo WangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Hongyu LiDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Shuanshuan FanDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Meijia SuCollege of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Shengyou LiDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Shijie YangDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an 710072, China.
Anhui QinDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Teng MaDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; Military Medical Innovation Center, Fourth Military Medical University, Xi'an 710032, China.
Xue GaoDepartment of Aerospace Physiology, Fourth Military Medical University, Xi'an 710032, China.
Huiling SunNew Cornerstone Science Laboratory, Shaanxi Key Laboratory of Qinling Ecological Intelligent Monitoring and Protection, School of Ecology and Environment, Northwestern Polytechnical University, Xi'an 710072, China.
Yiming HaoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Lingli GuoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Shihao NieDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jiaqi WangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhuojing LuoDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: zjluo@fmmu.edu.cn.
Jinghui HuangDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: huangjh@fmmu.edu.cn.
Bing XiaDepartment of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address: xiabing8807@fmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral nerve injury causes muscle atrophy due to slow axonal regeneration, highlighting an unmet therapeutic need. Although neuromuscular interactions are classically viewed as unidirectionally nerve dominated, we show that acutely denervated muscle (adMu) regulates nerve regeneration via a retrograde signaling pathway. adMu initiates a trans-tissue regulatory mechanism through extracellular vesicles (EVs

Indexed as

Extracellular VesiclesMitochondriaMuscle DenervationMuscle, SkeletalNeuronsPeripheral Nerve InjuriesAnimalsEnergy MetabolismFemaleMaleNerve RegenerationSciatic NerveSignal Transductionacute denervationextracellular vesiclesmitochondrial metabolismmuscleperipheral nerve injury

Identifiers

PMID41638198
PMCPMC12923977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.