Evidence map›Paper›PMID 41637763›Full record

ArticleNeurobiology of aging2026

ABCA7 rs115550680 risk allele carriers have lower medial temporal lobe dynamic network flexibility than APOE-ε4 allele carriers among older African Americans.

Miray Budak, Bernadette A Fausto, Victoria Paruzel, Payton White, Martina Ishaq, Soodeh Moallemian, Kelly N Nudelman, Mark A Gluck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miray BudakCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: miray.budak@rutgers.edu.
Bernadette A FaustoCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: bernadette.fausto@rutgers.edu.
Victoria ParuzelCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: wtp18@newark.rutgers.edu.
Payton WhiteCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: pw352@newark.rutgers.edu.
Martina IshaqCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: martina.ishaq@rutgers.edu.
Soodeh MoallemianCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: s.moallemian@rutgers.edu.
Kelly N NudelmanDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, 410 W. 10th Street, Indianapolis, IN 46202, USA. Electronic address: kholohan@iu.edu.
Mark A GluckCenter for Molecular and Behavioral Neuroscience, Rutgers University-Newark, 197 University Ave., Suite 209, Newark, NJ 07102, USA. Electronic address: gluck@newark.rutgers.edu.

Funding

Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans SUPPLEMENTR01AG053961 · NIA · RUTGERS THE STATE UNIV OF NJ NEWARK · PI MARK A GLUCK · 2018 to 2026
$10.6M
NIA NIH HHS R01 AG053961
6 · The paper itself

Abstract

Alzheimer's disease (AD) pathology disrupts functional brain connectivity long before symptoms emerge. African Americans face elevated AD risk, yet underlying mechanisms remain unclear. Genetic risk differs by ancestry: APOE-ε4 strongly predicts late-onset AD in European ancestry, whereas ABCA7 rs115550680 confers substantial risk in African ancestry. Yet, how these variants influence neural function in African Americans is unclear. The medial temporal lobe (MTL) is an early target of AD pathology and resting-state functional Magnetic Resonance Imaging (rs-fMRI) measures of dynamic network connectivity (hereafter "flexibility"), the brain's capacity to dynamically reconfigure connectivity, provide a sensitive metric of network adaptability, potentially preceding structural decline. However, comparative influence of APOE-ε4 and ABCA7 rs115550680 on MTL flexibility and subregional volumes in this population is unknown. 146 older African Americans (Mean

Indexed as

AllelesAlzheimer DiseaseApolipoprotein E4ATP-Binding Cassette TransportersBlack or African AmericanGenetic Association StudiesHeterozygoteNerve NetTemporal LobeAgedAged, 80 and overFemaleGenetic Predisposition to DiseaseGenotypeHumansMagnetic Resonance ImagingABCA7 protein, humanApolipoprotein E4ATP-Binding Cassette TransportersABCA7African AmericansAlzheimer’s diseaseAPOE-ε4Dynamic functional connectivityMedial temporal lobeNetwork flexibility

Identifiers

PMID41637763
PMCPMC13080515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.