Evidence map›Paper›PMID 41637720›Full record

ArticleNeural computation2026

Neuromodulators Generate Multiple Context-Relevant Behaviors in Recurrent Neural Networks.

Ben Tsuda, Stefan C Pate, Kay M Tye, Hava T Siegelmann, Terrence J Sejnowski

Abstract read
In one paragraph

Article in Neural computation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Diffusion of neuromodulators for temporal credit assignment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Structured flexibility in recurrent neural networks via neuromodulation.Advances in neural information processing systems · 2024
    Article
  3. Article
  4. Recent Advances at the Interface of Neuroscience and Artificial Neural Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ben TsudaComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA btsuda@mgh.harvard.edu.
Stefan C PateComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA stefan.pate@northwestern.edu.
Kay M TyeSystems Neuroscience Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA tye@salk.edu.
Hava T SiegelmannBiologically Inspired Neural and Dynamical Systems Laboratory, School of Computer Science, University of Massachusetts Amherst, Amherst, MA, 01003 hava@umass.edu.
Terrence J SejnowskiComputational Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Funding

Neural Circuit Mechanisms of Social Homeostasis in Individuals and Supraorganismal Social GroupsDP1AT009925 · NCCIH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TYE, KAY MAXINE · 2017 to 2021
$6.4M
Solving the Valence Assignment ProblemR37MH102441 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Kay Maxine Tye · 2021 to 2026
$5.6M
Temporal Context in Brains and TransformersDP1NS149613 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TERRENCE J SEJNOWSKI · 2025 to 2026
$2.6M
NCCIH NIH HHS DP1 AT009925NIMH NIH HHS R37 MH102441NINDS NIH HHS DP1 NS149613
6 · The paper itself

Abstract

Neuromodulators are critical controllers of neural states, with dysfunctions linked to various neuropsychiatric disorders. Although many biological aspects of neuromodulation have been studied, the computational principles underlying how neuromodulation of distributed neural populations controls brain states remain unclear. In contrast to external contextual inputs, neuromodulation can act as a single scalar signal that is broadcast to a vast population of neurons. We model the modulation of synaptic weight in a recurrent neural network model and show that neuromodulators can dramatically alter the function of a network, even when highly simplified. We find that under structural constraints like those in brains, this provides a fundamental mechanism that can increase the computational capability and flexibility of a neural network. Diffuse synaptic weight modulation enables storage of multiple memories using a common set of synapses that are able to generate diverse, even diametrically opposed, behaviors. Our findings help explain how neuromodulators unlock specific behaviors by creating task-specific hyperchannels in neural activity space and motivate more flexible, compact and capable machine learning architectures.

Indexed as

Models, NeurologicalNeural Networks, ComputerNeuronsNeurotransmitter AgentsAnimalsHumansRecurrent Neural NetworksSynapsesNeurotransmitter Agents

Identifiers

PMID41637720
PMCPMC13492707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.