Evidence map›Paper›PMID 41637678›Full record

ArticleEnvironmental microbiology reports2026

Bacterial Communities as Modulators of Innate Immune Signalling: An In Vitro Perspective on Toll-Like Receptor Activation.

Elke Eriksen, Pål Graff, Anani Komlavi Afanou

Abstract read
In one paragraph

Article in Environmental microbiology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elke EriksenSTAMI, National Institute of Occupational Health, Research Group for Chemical Work Environment, Oslo, Norway.ORCID https://orcid.org/0000-0002-9868-1347
Pål GraffSTAMI, National Institute of Occupational Health, Research Group for Chemical Work Environment, Oslo, Norway.ORCID https://orcid.org/0000-0003-4928-617X
Anani Komlavi AfanouSTAMI, National Institute of Occupational Health, Research Group for Occupational Toxicology, Oslo, Norway.ORCID https://orcid.org/0000-0001-6140-7312

Funding

IVAR-IKSNational institute of occupational health, Oslo (STAMI)Norwegian Union of Municipal and General Employees (NUMEG)The federation of Norwegian Industries
6 · The paper itself

Abstract

Investigating the work-environmental microbiome is critical for assessing occupational risk associated with exposure to microorganisms. The present study examined the bacterial composition of inhalable dust from waste sorting plants and explored their potential to induce Toll-like receptors (TLR) in vitro, thereby providing insights into the immunomodulatory potential of complex microbial communities from occupational settings. These findings highlight how few dominant bacterial species shape the immune activation properties of the overall bacterial community, where less abundant taxa play a crucial role in immune modulation through TLR activation. The strong association between TLR activation and rare yet highly inductive bacterial taxa demonstrates their potential immunological significance, suggesting that even low-abundant microbes may have a disproportionate impact on immune responses and occupational health outcomes.

Indexed as

BacteriaImmunity, InnateMicrobiotaToll-Like ReceptorsDustHumansInnate Immunity RecognitionSignal TransductionDustToll-Like Receptorsbacteriahigh throughput sequencingtoll‐like receptorswork environment

Identifiers

PMID41637678
PMCPMC12872116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.