ArticleBlood advances2026
Impact of rituximab maintenance on survival in patients with mantle cell lymphoma: a population-based cohort study.
Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in targeted and cellular therapies for relapsed/refractory mantle cell lymphoma: immunotherapeutic strategies and challenges.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractNewly diagnosed mantle cell lymphoma (MCL) is commonly treated with rituximab (R), combined with anthracycline-based chemotherapy, with or without autologous stem cell transplantation (ASCT). Although R maintenance (RM) in clinical trials has been shown to prolong overall survival (OS), its impact at the population level remains largely unknown. This study evaluated the effect of RM on the outcome of patients with MCL. Patients aged ≥18 years, who were diagnosed with MCL between 1989 and 2020 were identified using the Netherlands Cancer Registry and were categorized into periods that reflected R and RM implementation (1989-2000, 2001-2014, 2015-2020). The treatment strategies were categorized as R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone); R-CHOP, followed by high-dose cytarabine (intensive) and ASCT; and other. The primary end point was 5-year OS. A multivariable analysis (MVA) was performed using Cox regression. Among 4751 patients, the 5-year relative survival (RS) improved from 38% (1989-2000) to 47% (2001-2014) and 60% (2015-2020) (P< .01), irrespective of age (≤65 years: 32% vs >65 years: 20% increase over time). Patients with progression within 12 months had a 2-year OS rate of 25%. Since 2014, RM implementation reached 80% in younger patients and 50% in older patients. RM was associated with improved OS, especially for patients in partial remission (PR) after induction treatment with R-CHOP. In the MVA of patients treated with R-CHOP, RM was independently associated with reduced mortality (hazard ratio, 0.69; 95% confidence interval, 0.53-0.90). The RS in MCL improved by >20% in 30 years. Early disease progression remains associated with poor outcome. RM was associated with improved survival, especially among patients who achieved PR following R-CHOP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.