Evidence map›Paper›PMID 41637585›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mechanical Strain-Programmed SDC1

Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiajie LinDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Zepeng SuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Yipeng ZengDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Yi ZhouDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Chenying ZengCenter for Biotherapy, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Weihao ZhangDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Qibo LiDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Zipeng XiaoDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Zibin ChenDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Ziqian LiuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Yangfeng LinDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Guan ZhengDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Wenhui YuDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.
Zhongyu XieDepartment of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, P. R. China.ORCID https://orcid.org/0000-0003-2665-6115

Funding

China Postdoctoral Science Foundation 2024M763796Futian Healthcare Research Project FTWS016Futian Healthcare Research Project FTWS2022016National Natural Science Foundation of China 82272448National Natural Science Foundation of China 82402764Natural Science Foundation of Guangdong Province 2023A1515030026Natural Science Foundation of Guangdong Province 2023A1515111078Shenzhen Medical Research Fund A2403047Shenzhen Science and Technology Innovation Program JCYJ20240813150720026Shenzhen Science and Technology Innovation Program RCBS20221008093103013
6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is an osteoimmune disease characterized by pathological enthesitis related to mechanical strain. However, the cell interactions and molecular mechanisms of AS enthesitis are still unclear. Herein, we constructed a hind paw loading/unloading model using experimental spondyloarthritis SKG mice, and generated a single-cell RNA sequencing atlas of mechanical strain-related AS enthesitis. In this context, a disease-specific subpopulation of SDC1

Indexed as

FibroblastsNeutrophilsReceptors, CXCR4Spondylitis, AnkylosingSyndecan-1AnimalsDisease Models, AnimalHumansMiceStress, MechanicalCXCR4 protein, mouseReceptors, CXCR4Syndecan-1ankylosing spondylitisenthesitisfibroblastmechanical strainneutrophil

Identifiers

PMID41637585
PMCPMC13073239

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.