Evidence map›Paper›PMID 41637545›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single-Cell RNA Sequencing.

Xiheng Hu, Wensheng Shi, Liang Dong, Lingjuan Huang, Xiyuan Zhang, Yiting Feng, Jie Sun, Lanlan Liu, Teng Liu, Jun Fu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xiheng HuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wensheng ShiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liang DongNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China.
Lingjuan HuangNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China.
Xiyuan ZhangNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China.
Yiting FengNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China.
Jie SunClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Lanlan LiuClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Teng LiuClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Jun FuClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Bowen ZhongDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qihao LengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaohua WuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Minfeng ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingfang LiDepartment of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
Yuan LiDepartment of Urology, the Second Xiangya Hospital, Central South University, Changsha, China.
Xin JinDepartment of Urology, the Second Xiangya Hospital, Central South University, Changsha, China.
Long WangDepartment of Urology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jian CaoDepartment of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Xin LiClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.
Mingzhu YinClinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.ORCID https://orcid.org/0000-0002-6964-7131
Xiang ChenNational Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha, Hunan, China.

Funding

Chongqing Health Commission and Science and Technology Bureau 2025QNKX004Chongqing Wanzhou District PhD Direct-Access Research Project wzstc-20240006Hunan Youth Talent Program for Distinguished Scholars 2024RC3045National Key R&D Programmes (NKPs) of China 2022YFC3601800Natural Science Foundation of Hunan Province of China 2023JJ30883Natural Science Foundation of Hunan Province of China 2024JJ6703New Chongqing Youth Innovation Talent Project CSTB2025YITP-QCRCX0005Science Fund for Distinguished Young Scholars of Hunan Province 2021JJ10073
6 · The paper itself

Abstract

Penile squamous cell carcinoma (PSCC) is a rare genitourinary malignancy, and factors of its tumor microenvironment (TME) could serve as prognostic indicators for tumor recurrence and metastasis. Here, we generated a comprehensive single-cell map of PSCC (66 421 cells) and identified 9 distinct cell populations with samples from nine tumor samples and six adjacent normal samples. Among the malignant cells, SEMA3C

Indexed as

Carcinoma, Squamous CellPenile NeoplasmsBiomarkers, TumorDisease ProgressionEpithelial-Mesenchymal TransitionHumansMalePeriostinPrognosisSemaphorinsSequence Analysis, RNASingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTumor MicroenvironmentBiomarkers, TumorPeriostinSemaphorinsPSCCSEMA3CSEMA3Chigh Malssingle‐cell RNA sequencingTME

Identifiers

PMID41637545
PMCPMC12970255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.