Evidence map›Paper›PMID 41637523›Full record

ArticleScience translational medicine2026

Kras G12C- and G12D-driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models.

Hai-Cheng Huang, Qing Deng, Lei Guo, Teresa Gorria, Federica Pecci, Daniella Yang, Scott Rodig, Luis De Las Casas, Jill Hallin, James G Christensen and 4 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hai-Cheng HuangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2369-6288
Qing DengDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9835-6889
Lei GuoQuantitative Biomedical Research Center, Department of Population & Data Sciences, Dallas, TX 75390, USA.
Teresa GorriaLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Federica PecciLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Daniella YangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2836-6755
Scott RodigDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Luis De Las CasasDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jill HallinMirati Pharmaceuticals (a Bristol Myers Squibb company), San Diego, CA 92121, USA.ORCID 0000-0002-8443-7116
James G ChristensenMirati Pharmaceuticals (a Bristol Myers Squibb company), San Diego, CA 92121, USA.
Mark M AwadLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.ORCID 0000-0003-0928-5244
Lin XuHarold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA.ORCID 0000-0001-5815-4457
Biagio RicciutiLowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Esra A AkbayDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4149-2529

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4M
Development of a RUVBL1/2 Inhibitor as a Radiosensitizer and Immune Stimulator for NSCLCR01CA276058 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Esra Akbay, Anthony J Davis · 2023 to 2026
$2.2M
Overcoming Therapy Resistance in SCLCR01CA289500 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Esra Akbay · 2024 to 2026
$1.5M
NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA276058NCI NIH HHS R01 CA289500
6 · The paper itself

Abstract

The development of allele-specific KRAS inhibitors underscores the importance of understanding the distinct tumor biology associated with common

Indexed as

AllelesLung NeoplasmsMutationProto-Oncogene Proteins p21(ras)AnimalsCarcinogenesisDisease Models, AnimalImmune Checkpoint InhibitorsImmunogenetic PhenomenaMiceImmune Checkpoint InhibitorsKras protein, mouseProto-Oncogene Proteins p21(ras)

Identifiers

PMID41637523
PMCPMC13109965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.