Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Qiong ZhuState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0009-0004-8548-2607
Jinning ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0002-7967-8425
Weichen ZhouDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4755-1072
Shen-Ao LiangState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0009-0001-8089-5881
Shengmiao WangDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0009-0005-0460-9416
Xinyu CaiDepartment of Life Sciences, Imperial College London, London SW7 2AZ, UK.ORCID 0009-0002-3999-3524
Fuyuan LiDepartment of Cell and Development Biology, State Key Laboratory of Genetics and Development of Complex Phenotypes and School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0000-0002-2981-234X
Jin LiDepartment of Cell and Development Biology, State Key Laboratory of Genetics and Development of Complex Phenotypes and School of Life Sciences, Fudan University, Shanghai 200433, China.ORCID 0000-0002-7957-1476
Guojie ZhangCenter for Evolutionary and Organismal Biology, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0000-0001-6860-1521
Huijuan FengDepartment of Computational Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0002-4005-560X
Qiaomei FuKey Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.ORCID 0000-0002-7141-0002
Joshua M AkeyThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.ORCID 0000-0002-4411-1330
Feng ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0003-4556-8276
Li JinState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0001-9201-2321
Shuhua XuState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0002-1975-1002
Hong-Xiang ZhengState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0000-0003-1637-0375
Lu ChenState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, School of Life Science, Fudan University, Shanghai 200438, China.ORCID 0009-0000-1576-9486
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Archaic introgression introduced functionally relevant variants into modern humans, yet small-scale insertions remain understudied. Here, we leverage 2519 modern human genomes and four high-coverage archaic hominin genomes to systematically characterize nuclear mitochondrial DNA segments (NUMTs). We uncover 483 polymorphic NUMTs across globally diverse human populations and 10 in archaic genomes. By combining overlap with Neanderthal-derived and Denisovan-derived haplotypes, phylogenetic analyses, insertion time estimates, and haplotype colocalization, we identify five NUMTs introduced into modern humans via archaic hominin introgression. Functional analyses reveal that introgressed NUMTs can modulate gene expression, including allele-specific up-regulation of the immune-related gene
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Introgressed mitochondrial fragments from archaic hominins alter nuclear genome function in modern humans. · full record | OpenQuestion