Association between triglyceride-cholesterol-body weight index and sarcopenia in the older adults from China: A cross-sectional study.

Yanmei Ning, Doudou Li, Ting Zhang, Jiana Shi, Ying Hu

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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Associations of cumulative exposure and dynamic trajectories of the triglyceride-total cholesterol-body weight index with new-onset cardiometabolic multimorbidity in middle-aged and older Chinese adults: evidence from a nationwide prospective cohort study.Cardiovascular diabetology · 2026
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5 authors.

Yanmei NingSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.

Doudou LiClinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Af-filiated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Ting ZhangClinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Af-filiated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Jiana ShiClinical Pharmacy Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Af-filiated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Ying HuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0009-0002-6067-5029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe triglyceride-cholesterol-body weight index (TCBI) is a simple and reliable indicator of nutritional status. This investigation aimed to explore the association between TCBI and sarcopenia among older individuals in China.

methodsThe AWGS 2019 criteria were utilized to evaluate sarcopenia. TCBI was calculated as (TG × TC × BW)/1000. Logistic regression analysis explored the independent connection between TCBI and the occurrence of sarcopenia. RCS was employed to investigate both linear and nonlinear correlations, and threshold effects were scrutinized. Furthermore, subgroup and sensitivity analyses were also conducted.

resultsThis study included 5293 participants. The TCBI was found to be negatively associated with sarcopenia in a fully corrected model, with a 66% decrease in the prevalence of sarcopenia for each 1-unit increase in LgTCBI (OR = 0.34; 95% CI: 0.28-0.41; p < 0.001). The study showed that this association was further highlighted in those with normal BMI and remains consistent in sensitivity analyses. Furthermore, we found a nonlinear association between both TCBI and sarcopenia, with an inflection point of 7.05 by the RCS curve and threshold effect analysis.

conclusionThis study revealed a nonlinear negative correlation between TCBI and sarcopenia, highlighting the implications of these findings for the early screening and timely intervention of sarcopenia.

Indexed as

Body WeightCholesterolSarcopeniaTriglyceridesAgedAged, 80 and overBody Mass IndexChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedCholesterolTriglycerides

Identifiers

PMID41637476

DOI10.1371/journal.pone.0342265

PMCPMC12922771

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