Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Simona Dalin *Cancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0000-0001-5024-9718
Sophie Webster *Cancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.ORCID 0009-0001-7367-6306
Neal Sugawara *Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Qiuqin WuRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Shu ZhangCancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Carmen MaciasRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Elena SapèdeRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Tracy CuiCancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
Victoria LiangRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Laura TranRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Rameen BeroukhimCancer Program, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.
James E HaberRosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.ORCID 0000-0002-1878-0610
Funding
DNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6M
Genetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9M
Synthetic lethalities to cell cycle disruption in gliomaR01CA262462 · NCI · DANA-FARBER CANCER INST · PI RAMEEN BEROUKHIM, KEITH LLOYD LIGON · 2022 to 2026
$3.3M
Break Through Cancer (BTC) PS6427002Gray Matters Brain Cancer Foundation donationHHS | NIH | National Institute of General Medical Sciences (NIGMS) 1K99GM155595HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM127029HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI) 1F32CA261024HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI) R01CA188228HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI) R01CA262462NIGMS NIH HHS R35 GM127029Pediatric Brain Tumor Foundation (PBTF) A novel therapeutic target for KIAA1549-BRAF-rearranged pediatric gliomas
6 · The paper itself
Abstract
Double-strand break (DSB) repair is highly mutagenic compared to normal replication. In budding yeast, repair of an HO (homothallism) endonuclease-induced DSB at the mating-type α locus (
Indexed as
DNA Breaks, Double-StrandedDNA RepairMutationBase SequenceDNA, FungalDNA ReplicationKluyveromycesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA, FungalSaccharomyces cerevisiae ProteinsURA3 protein, S cerevisiaeDNA repairmicrohomologymutationtemplate switchingyeast
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mutations and structural variants arising during double-strand break repair. · full record | OpenQuestion