ArticleCritical care science2026
Evolutive acid-base derangements in critically ill patients: epidemiological aspects, association with mortality and metabolic acidosis prediction.
Article in Critical care science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Severe alkalemia in the emergency department : Acid-base patterns, clinical presentation and short-term outcomes in hospitalized patients.Wiener klinische Wochenschrift · 2026Article
- Sodium bicarbonate in critical illness: Correcting acidaemia without changing outcomes?Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the prevalence and evolution of acid-base disturbances at intensive care unit admission and throughout hospitalization and their association with intensive care unit mortality.
methodsA retrospective epidemiological study was conducted, analyzing consecutive patients admitted to a single intensive care unit.
resultsMetabolic acidosis, either isolated or combined with other disturbances, was the most prevalent disorder (58.0%), followed by respiratory alkalosis (37.6%), respiratory acidosis (25.7%), and metabolic alkalosis (12.8%). Multivariate analysis demonstrated that metabolic alkalosis combined with respiratory alkalosis was independently associated with reduced mortality (OR 0.427, 95%CI 0.194 - 0.869). Higher standard base excess at intensive care unit admission was correlated with lower mortality (OR 0.973, 95%CI 0.956 - 0.990). Maximum pCO2 variation during hospitalization showed no significant association with mortality. However, greater standard base excess improvement was independently linked to reduced mortality in patients with intensive care unit stays exceeding 5 days. Additionally, disease severity markers and younger age were predictive of metabolic acidosis both at admission and during hospitalization.
conclusionMetabolic acidosis was the most common acid-base disorder at intensive care unit admission, with lower standard base excess levels associated with increased mortality. Standard base excess improvement during prolonged intensive care unit stays correlated with improved survival. Disease severity indicators were predictive of metabolic acidosis upon admission and throughout hospitalization.
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