ReviewBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas2026
An overview on central nervous system tuberculosis (CNS-TB) focusing on cognitive impairments.
Review in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bacillus Calmette-Guérin (BCG) Vaccination and the Immune-Brain Axis: Implications for Neuroprotection and Neurodegenerative Disease.Vaccines · 2026Review
- Immune-inflammatory profiles and disease severity in pulmonary tuberculosis complicated by central nervous system tuberculosis.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most serious clinical manifestations of tuberculosis (TB) is the central nervous system (CNS) presentation, which results in neurological disorders and cognitive impairments that may lead to reduced social skills. Few studies have assessed TB neuropsychological symptoms after infection. This review article investigated the incidence and spectrum of cognitive impairment related to complications in patients with CNS-TB and compiled data on the pathophysiology, diagnosis, and treatment of the disease. An extensive literature review was performed, and a total of 286 published studies were selected for manual screening. For analysis purposes, 43 studies were included in this review. CNS-TB mainly affects young children and is fatal in over 50% of cases, with survivors showing high morbidity. The characteristics of this disease include meningitis and brain tissue granulomas. This leads to extensive neurological involvement, resulting in a complex mechanism that alters the structure and composition of cells in the brain including the cerebellum and spinal cord. It also impairs language development, reading, and learning complex tasks, and therefore affects the patient's social adjustment. The results of our review provide information connecting the basis of neuroscience and clinical medicine, especially childcare. Furthermore, early diagnosis is imperative to prevent serious cognitive consequences of TB in the developing CNS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.