Evidence map›Paper›PMID 41637266›Full record

ArticleCoDAS2026

Interpeak intervals of cortical components (P1-N1-P2): a comparative study between typical individuals and those with tinnitus disorder.

Hélinton Goulart Moreira, Christine Grellmann Schumacher, João Vitor de Aguiar Barcelos, Bruna Ribas Maia, Fabiana Cristina Toillier, Larissa Coradini, Isabela Pohlmann de Ávila Lourenço, Pedro Vinícius de Godoy Ferrão, Dayane Domeneghini Didoné, Michele Vargas Garcia

Abstract readComparative Study
In one paragraph

Article in CoDAS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hélinton Goulart MoreiraPrograma de Pós-graduação em Distúrbios da Comunicação Humana, Departamento de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0000-0001-5212-7546
Christine Grellmann SchumacherPrograma de Pós-graduação em Distúrbios da Comunicação Humana, Departamento de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0000-0003-0732-6815
João Vitor de Aguiar BarcelosCurso de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0006-2581-669X
Bruna Ribas MaiaCurso de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0007-9533-9769
Fabiana Cristina ToillierCurso de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0001-3729-0414
Larissa CoradiniUniversidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0003-9576-7537
Isabela Pohlmann de Ávila LourençoCurso de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0009-8038-3470
Pedro Vinícius de Godoy FerrãoCurso de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0009-0004-9558-6522
Dayane Domeneghini DidonéPrograma de Pós-graduação em Distúrbios da Comunicação Humana, Departamento de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0000-0002-0363-5613
Michele Vargas GarciaPrograma de Pós-graduação em Distúrbios da Comunicação Humana, Departamento de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.ORCID http://orcid.org/0000-0003-3779-349X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare neural response times among cortical components of the Long-Latency Auditory Evoked Potential (LLAEP) by measuring latency and interpeak intervals in individuals with and without tinnitus.

methodThis was an analytical, cross-sectional, and quantitative study. A total of 28 participants were included, divided into two groups: the Control Group, comprising 12 individuals without tinnitus perception, and the Study Group, comprising 16 individuals diagnosed with tinnitus disorder. Assessments were conducted over two sessions. Initially, all participants underwent a semi-structured anamnesis, basic audiological evaluation, behavioral tests of central auditory processing, as well as neuropsychological and tinnitus assessments. On the second day, verbal LLAEP and neurodiagnostic ABR were performed. The responses were compared by analyzing the latency of P1, N1, and P2 potentials. A between-group comparison was conducted using an independent sample t-test.

resultsA statistically significant difference was observed in the interpeak intervals of P1-P2 potentials, as well as a trend toward significance in N1-P2 interpeak intervals between groups in the right ear. Additionally, a significant difference was found in P1-P2 interpeak intervals between groups in the left ear.

conclusionIndividuals with tinnitus disorder exhibited longer interpeak intervals, suggesting central auditory processing dysfunction and increased neural response within auditory processing pathways.

Indexed as

Evoked Potentials, AuditoryTinnitusAcoustic StimulationAdultCase-Control StudiesCross-Sectional StudiesEvoked Potentials, Auditory, Brain StemFemaleHumansMaleMiddle AgedReaction TimeYoung Adult

Identifiers

PMID41637266
PMCPMC12978340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.