Evidence map›Paper›PMID 41637252›Full record

ArticleJournal of applied oral science : revista FOB2026

Diversity of Streptococcus mutans serotypes isolated from dental plaque of Brazilian patients with a history of acute myocardial infarction.

Francisco Ruliglésio Rocha, Wanessa Fernandes Matias Regis, Rochelle Pinheiro Ribeiro, João Eudes Teixeira Pinho Filho, Tiago Lima Sampaio, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Lidiany Karla Azevedo Rodrigues

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Article in Journal of applied oral science : revista FOB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francisco Ruliglésio RochaUniversidade Federal do Ceará, Programa de Pós-Graduação em Microbiologia Médica, Departamento de Patologia e Medicina Legal, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-6763-8370
Wanessa Fernandes Matias RegisUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Programa de Pós-Graduação em Odontologia, Departamento de Odontologia Restauradora, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-2755-7672
Rochelle Pinheiro RibeiroHospital Universitário Walter Cantídio, Fortaleza, CE, Brasil.ORCID http://orcid.org/0009-0007-5946-4140
João Eudes Teixeira Pinho FilhoUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Programa de Pós-Graduação em Odontologia, Departamento de Odontologia Restauradora, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-5785-5910
Tiago Lima SampaioUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Análises Clínicas e Toxicológicas, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-8839-5072
Raquel Carvalho MontenegroUniversidade Federal do Ceará, Faculdade de Medicina, Departamento de Fisiologia e Farmacologia, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-3861-293X
Ana Paula Negreiros Nunes AlvesUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Programa de Pós-Graduação em Odontologia, Departamento de Odontologia Restauradora, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0002-5090-6877
Lidiany Karla Azevedo RodriguesUniversidade Federal do Ceará, Programa de Pós-Graduação em Microbiologia Médica, Departamento de Patologia e Medicina Legal, Fortaleza, CE, Brasil.ORCID http://orcid.org/0000-0001-8060-8531

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStreptococcus mutans serotypes (c, e, f, k) are linked to dental caries, with less common serotypes (e, f, k) and collagen-binding genes (CBG: cnm and cbm) suggested to be associated with cardiovascular diseases.

objectiveThis study investigated the presence of S. mutans serotypes and collagen-binding genes (CBGs) in dental plaque and their possible association with acute myocardial infarction (AMI) in adults. METHODOLOGY: A total of 31 infarcted and 17 non-infarcted patients underwent oral and blood examinations. DNA from plaque samples was analyzed using PCR to identify S. mutans serotypes and cnm/cbm genes. S. mutans was detected in 22.6% (7/31) of infarcted patients and 11.8% (2/17) of non-infarcted patients.

resultsSerotype c was the most prevalent in infarcted patients (57.1%, 4/7), followed by e (42.9%, 3/7) and k (14.3%, 1/7); serotype f was not detected. Only serotype c was found in non-infarcted patients. Less common serotypes (e, k) and co-occurring serotypes (c, k) were exclusive to infarcted patients. No CBGs were detected in any serotypes. No association was found between S. mutans and dental caries in either group. Patients with cholesterol levels <190 mg/dL and no S. mutans had a 47.4% lower risk of infarction.

conclusionAlthough S. mutans, including less common serotypes, was more prevalent in infarcted patients, no significant association with AMI was observed. Further research is needed to elucidate the role of S. mutans in cardiovascular diseases.

Indexed as

Dental PlaqueMyocardial InfarctionStreptococcus mutansAdultAgedBrazilCase-Control StudiesDental CariesDNA, BacterialFemaleHumansMaleMiddle AgedPolymerase Chain ReactionSerogroupSerotypingDNA, Bacterial

Identifiers

PMID41637252
PMCPMC13123788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.