Evidence map›Paper›PMID 41637185›Full record

ArticleCell reports2026

ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils.

Som Dev, Yu Wang, Moonjung Jung, Yingze Ma, Sepehr Mani, Ekaterina Kabin, Ridzky Yuda, Yixuan Dong, Martina Ralle, James P Hamilton and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Som DevDepartment of Biochemistry, All India Institute of Medical Sciences, Kalyani, West Bengal 741245, India; Department of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address: som.biochem@aiimskalyani.edu.in.
Yu WangDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Moonjung JungDivision of Hematology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA; Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA; Department of Genetic Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Yingze MaDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Sepehr ManiDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Ekaterina KabinDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Ridzky YudaDivision of Hematology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Yixuan DongDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Martina RalleDepartment of Molecular and Medical Genetics, OHSU, Portland, OR, USA.
James P HamiltonDivision of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address: jpahamilton@jhmi.edu.
Svetlana LutsenkoDepartment of Physiology, Pharmacology & Therapeutics, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA; Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA. Electronic address: lutsenko@jhmi.edu.

Funding

Copper Homeostasis and Liver FunctionR01DK117396 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JAMES P HAMILTON, SVETLANA LUTSENKO · 2018 to 2026
$3.9M
Protection of hematopoietic stem progenitor cells from endogenous DNA damageR00HL177829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Moonjung Jung · 2025 to 2026
$753k
Inductively Coupled Plasma Mass Spectrometer for High Sensitivity Elemental AnalysisS10OD028492 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2021 to 2021
$336k
NHLBI NIH HHS R00 HL177829NIDDK NIH HHS R01 DK117396NIH HHS S10 OD028492
6 · The paper itself

Abstract

Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles and store Cu in vesicles. During neutrophil differentiation, ATP7B is downregulated, whereas ATP7A, LOXL2, and SLC31A2 are induced, suggesting a coordinated switch from Cu storage to utilization. As mature neutrophils exit the bone marrow, cellular Cu levels drop markedly, indicating Cu release during late maturation or egress. Myeloid-specific deletion of Atp7b in mice uncouples lineage commitment from functional maturation: Atp7b-deficient cells differentiate into neutrophils but fail to mature fully, showing more mitochondria, fewer lysosome-like structures, lower abundance of Cebp-ε and Ngal, reduced tubulin levels, and disrupted microtubules. Following lipopolysaccharide injection, Atp7b-deficient bone marrow releases fewer neutrophils into the bloodstream. Together, these findings reveal a previously unrecognized role of the Cu-transport network in neutrophil maturation and egress.

Indexed as

CopperCopper-Transporting ATPasesMyeloid Progenitor CellsNeutrophilsAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutAtp7b protein, mouseCopperCopper-Transporting ATPasesATP7AATP7BCEBPεcopperCP: immunologyCP: metabolismmouse modelmyeloid differentiationneutrophil maturation

Identifiers

PMID41637185
PMCPMC13097107

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.