ArticleDigestive diseases and sciences2026
Adipokine CTRP12 Alleviates Experimental Colitis by Participating in Modulating Mesenteric M2 Macrophage Polarization in IL-10 KO Mice.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Enhancing colonic anastomotic healing with a novel melatonin-loaded PLGA matrix.Experimental physiology · 2026Article
- A Bidirectional C1q/TNF-Related Protein Signature Is Associated with Disease Activity in Behçet's Disease: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeCrohn's disease is a chronic inflammatory bowel disease of unknown etiology. Mesentery dysfunction and aberrant adipokine levels participate in the pathogenesis of Crohn's disease. Macrophage polarization plays important roles in mesenteric inflammation. This study aimed to explore the expression of adipokine CTRP12 in Crohn's disease patients and possible roles using IL-10 deficient (Il-10
methodsExpression of CTRP12 in mesentery adipose tissue specimens from Crohn's patients (n = 20) and control patients (n = 10) was detected. Il-10
resultsOur findings indicate CTRP12 is highly expressed in the mesentery of Crohn's patients. CTRP12 treatment can reduce intestinal and mesenteric inflammation in chronic colitis model with CD-like features and can promote the polarization of mesenteric macrophages to M2 type, possibly related to the activation of TGFβRII/Smad signaling pathway.
conclusionThese findings suggest adipokine CTRP12 could ameliorate Crohn's colitis by modulating polarization of mesenteric macrophages to M2 type, providing new target for Crohn's disease therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.