Evidence map›Paper›PMID 41637031›Full record

ReviewCurrent medical science2026

Epigenetic Modulation by Vitamin C and in Prenatal Depression: Implications for Offspring Health.

Jia-Shuang Xu, Ying Li, Li-Qing Wei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jia-Shuang Xu *Wuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, 430016, China.
Ying Li *Physical Examination Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Li-Qing WeiWuhan Wuchang Hospital, Wuhan University of Science and Technology, Wuhan, 430016, China. zhezhu2020@whu.edu.cn.

Funding

Joint Fund of Hubei Provincial Key Laboratory for Occupational Hazard Identification and Control JF2024-G17Natural Science Foundation of Hubei Province 2025AFB830
6 · The paper itself

Abstract

Prenatal depression is a prevalent mental health disorder that adversely affects maternal well-being and offspring health. Emerging evidence suggests that vitamin C (L-ascorbic acid), a key antioxidant, may influence this process through the regulation of DNA methylation (DNAm)-a critical epigenetic mechanism governing gene expression. This review summarizes current research on the role of vitamin C in modulating DNAm and explores its potential to mitigate the intergenerational impacts of prenatal depression. We analyze findings indicating that vitamin C may alleviate depressive symptoms and improve offspring health outcomes via epigenetic pathways. Furthermore, we highlight existing research gaps and propose future directions for investigation. By elucidating the interplay between vitamin C, epigenetic regulation, and prenatal depression, this article aims to provide novel insights for developing nutritional strategies to enhance maternal mental health and promote offspring well-being.

Indexed as

Ascorbic AcidDepressionEpigenesis, GeneticPrenatal Exposure Delayed EffectsAnimalsAntioxidantsDevelopmental Origins of Health and DiseaseDNA MethylationFemaleHumansPregnancyAntioxidantsAscorbic AcidAscorbic acidDNA methylationEpigenetic regulationMaternal nutritionOffspring healthPrenatal depressionTET enzymeVitamin C

Identifiers

PMID41637031

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.