Observational studyClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Futility in patients with peritoneal carcinomatosis of ovarian origin undergoing or who underwent interval cytoreductive surgery: a multicenter retrospective observational study.
Observational study in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe indicators of surgical outcomes are handy tools in health management. Futility is a very interesting indicator, because it defines those patients who have undergone a surgical procedure with its morbidity and mortality and who have not benefited from the treatment. Knowledge of the factors that influence futility can help us better select patients with carcinomatosis of ovarian origin.
methodsMulticenter study was performed. INCLUSION CRITERIA: > 18 years old, with ovarian cancer and peritoneal carcinomatosis, who underwent scheduled surgery after response to neoadjuvant therapy. The definition of Futility in ovarian peritoneal carcinomatosis was: all patients with non-CC-0, death in the first 90 days in the postoperative period or within the first year after surgery were considered futile patients.
resultsWe included 365 patients. 84 patients (23.6%) were in the futility group compared with 279 (73.4%) who were not in the futility group. We obtained that non-obtaining CC-0 was the main factor of futility (61.6%). The 2º crucial factor of futility was mortality in the first year after surgery. The incidence of futility in the series is 23.6%. Comparing futility and non-futility groups, we could observe statistically significant differences in hospital stay, higher levels of CA125 (52 vs. 35), and higher postoperative PCI. Patients in the futility group had almost twice PCIs as those who were not. When performing univariate regression, we could observe that PCI and the PCI distributed by categories (< 10; 11-20; > 20) were independent variables associated with futility.
conclusionPCI is a relevant factor in futility in ovarian cancer.
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