ArticleJournal of molecular histology2026
Therapeutic effect of naringenin against fenamiphos‑induced testicular damage in male rats: a histological and biochemical study.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Fenamiphos (FNP) is an organophosphate compound used to control many agricultural pests. Naringenin (NAR) is a compound that has been recognized as a having physiologically potent antioxidant activity. This study was made to detect the possible therapeutic effects of NAR in preventing fenamiphos-induced reproductive toxicity. For this purpose, rats were treated with Fenamiphos (FNP) and Naringenin (NAR) for 4 weeks. This study was conducted on a total of 24 adult male albino rats. The rats were divided in an equally random manner into four groups: Group 1 was determined as the control group; group II received a dose of 50 mg/kg naringenin orally; group III received fenamiphos in a dose of 0.76 mg/kg/day orally; group IV received both naringenin and fenamiphos in the same stated doses. The results obtained in the testis showed a significant increase in the malondialdehyde, 8-OHdG, IL-17, and a significant decrease in superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, acetylcholine esterase activities, testosterone, FSH, and LH contents in the FNP-treated group. Tissue damage induced significant histopathological/immunohistochemical changes following exposure to FNP. Treatment with NAR reduced malondialdehyde, 8-OHdG, and IL-17 contents, and naringenin treatment caused an increase in superoxide dismutase, catalase, glutathione-S-transferase, glutathione peroxidase, acetylcholine esterase, testosterone, FSH, and LH parameters compared with the FNP-treated groups. Micrographs of testis sections in FNP plus NAR-treated rats showed fewer histopathological and immunohistochemical changes. Flavonoids could effectively protect against fenamiphos-induced damage, offering a potential solution for pesticide-related toxicity. In this investigation, it was shown that fenamiphos caused testicular toxicity, and naringenin reduced this toxicity.
Indexed as
Identifiers
41636930What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.