Evidence map›Paper›PMID 41636916›Full record

ArticleMolecular biology reports2026

Antibacterial and synergistic effects of Shirazi thyme (Zataria multiflora) essential oil against methicillin-resistant Staphylococcus aureus.

Kimiya Kazemi Esfeh, Mitra Dadgar, Zahra Dargahi, Armin Khaleghjoo, Ehsan Ghasemi, Forouzan Absalan, Ebrahim Barzegari, Mostafa Jamalan

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kimiya Kazemi EsfehDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mitra DadgarDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Zahra DargahiDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Armin KhaleghjooDepartment of Pediatrics, Medical Faculty, Abadan University of Medical Sciences, Abadan, Iran.
Ehsan GhasemiDepartment of Microbiology, Medical Faculty, Abadan University of Medical Sciences, Abadan, Iran.
Forouzan AbsalanDepartment of Anatomy, Medical Faculty, Abadan University of Medical Sciences, Abadan, Iran.
Ebrahim BarzegariMedical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Mostafa JamalanDepartment of Biochemistry, Medical Faculty, Abadan University of Medical Sciences, P.O. Box: 6313833177, Abadan, Iran. mjamalanbiochem@abadanums.ac.ir.ORCID http://orcid.org/0000-0002-8151-2029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) is a significant public health concern due to its resistance to multiple antibiotics, primarily mediated by the gene mecA, which encodes penicillin-binding protein 2a (PBP2a), considering the growing global demand for novel antimicrobial strategies. MATERIALS AND

methodsA clinical MRSA strain harboring the gene mecA was identified. Antimicrobial susceptibility testing was performed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Shirazi thyme (Zataria multiflora) essential oil. The strain's susceptibility to multiple antibiotics was assessed and the synergistic effect of Z. multiflora essential oil and cefoxitin was also evaluated. Gas chromatography-mass spectrometry (GC-MS) was employed to identify the bioactive compounds in the essential oil. Molecular docking studies were performed to evaluate the competitive binding affinity of those compounds to PBP2x.

resultsThe MRSA strain exhibited resistance to all tested antibiotics except linezolid. The MIC and MBC values for Z. multiflora essential oil were 3.125 mg.mL

conclusionThe findings highlight the significant antibacterial activity of Z. multiflora essential oil against MRSA and its potential to enhance the efficacy of cefoxitin through synergistic interactions among the inhibitors of natural origin for PBP2x.

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusOils, VolatileBacterial ProteinsCefoxitinDrug SynergismGas Chromatography-Mass SpectrometryHumansMicrobial Sensitivity TestsMolecular Docking SimulationPenicillin-Binding ProteinsAnti-Bacterial AgentsBacterial ProteinsCefoxitinmecA protein, Staphylococcus aureusOils, VolatilePenicillin-Binding ProteinsAntibiotic resistanceMecA geneMethicillin-resistant Staphylococcus aureusMolecular dockingPBP2xZataria multiflora

Identifiers

PMID41636916

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