ReviewJournal of materials science. Materials in medicine2026
Exosome-loaded hydrogel systems for spinal cord injury repair: mechanisms, advancements, and future directions.
Review in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Plasticity, injury-induced reprogramming, and translational applications of Schwann cells in neural regeneration.Frontiers in cellular neuroscience · 2026Review
- Extracellular vesicle-based therapeutic strategies for spinal tumors and associated nerve damage: advances, challenges, and future directions.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite ongoing research efforts, spinal cord injury (SCI) remains one of the most disabling neurological disorders where current therapies provide limited solutions that mostly address symptoms rather than true regeneration. The latest research indicates that exosome-loaded hydrogel systems could function as a dual-purpose treatment for spinal cord injury in regenerative medicine. Exosomes are tiny membrane-enclosed extracellular vesicles that carry multiple therapeutic biomolecules which help control inflammation while delivering neuroprotective and tissue regenerative properties. The structural support and controlled release capabilities of hydrogels allow them to encapsulate exosomes which leads to their stable and bioactive delivery to the injury site. This study evaluates recent progress in exosome-loaded hydrogel technology for spinal cord injury repair by examining SCI mechanisms and the advantages of combining exosomes with hydrogels to develop optimized delivery systems. Our discussion will cover both the challenges of standardizing exosome production and hydrogel formulation as well as the scalability of these systems for in vivo applications. The following review will provide a summary of this novel SCI treatment approach and set out research directions to develop a therapy that is efficient, scalable, and translatable to humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.