Evidence map›Paper›PMID 41636879›Full record

ArticleBreast cancer research and treatment2026

Oncologic safety of prophylactic nipple-sparing mastectomy: Outcomes of 1,255 cases exceeding a 6-year median follow-up.

Thomas Amburn, Fatemeh P Parvin-Nejad, Varadan Sevilimedu, Huayue Zou, Giacomo Montagna, Tracy-Ann Moo, Mahmoud El-Tamer, Monica Morrow, Virgilio Sacchini

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Article in Breast cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas Amburn *Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.
Fatemeh P Parvin-Nejad *Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.
Varadan SevilimeduBiostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Huayue ZouBiostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Giacomo MontagnaBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.
Tracy-Ann MooBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA. moot@mskcc.org.
Mahmoud El-TamerBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.
Monica MorrowBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.
Virgilio SacchiniBreast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 300 E 66thSt, New York, NY, 10065, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProphylactic nipple-sparing mastectomy (PNSM) is performed to prevent the development of breast cancer. Despite the increasing usage of PNSM, large-cohort, long-term follow-up data is lacking. We aim to review a large cohort of PNSM cases to evaluate oncologic outcomes.

methodsWe retrospectively reviewed all PNSMs between 2000 and 2021 at a single institution. Clinicopathologic variables were collected and analyzed. Descriptive statistics and Kaplan Meier (KM) based survival analyses were used.

resultsA total of 1,255 PNSMs in 972 patients were performed from 2000 to 2021 with a median age of 43 years (IQR 37, 49) and a median follow-up of 81.3 months (IQR 50.8, 123.0). There were 38 (3.0%) cases of incidental breast cancer discovered on surgical pathology. There were 3 (0.3%) new primary breast cancer occurrences after PNSM. The KM estimates for 5-year rates in the entire cohort (n = 972) of incidence of new breast cancer, breast cancer-related mortality, and overall mortality were as follows: 0.15% (95%CI 0, 0.44%), 0.93% (95%CI 0.28%, 1.57%), and 1.63% (95%CI 0.78%, 2.48%), respectively. The KM estimates for 5-year rates in the BRCA-only cohort (n = 333) of incidence of new breast cancer, breast cancer-related mortality, and overall mortality were as follows: 0.44% (95%CI 0, 1.30%), 1.75% (95%CI 0.21%, 3.26%), and 2.09% (95%CI 0.42%, 3.73%), respectively.

conclusionNew primary breast cancer infrequently developed after PNSM in this study. Incidental breast cancer was identified on surgical pathology in a small subset of patients. PNSM may be associated with preventing breast cancer development.

Indexed as

Breast NeoplasmsNipplesOrgan Sparing TreatmentsProphylactic MastectomyAdultFemaleFollow-Up StudiesHumansMiddle AgedRetrospective StudiesTreatment OutcomeBreast oncologyMastectomyNipple-sparingOncologic safetyProphylactic

Identifiers

PMID41636879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.