Trial reportExperimental physiology2026
On-feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation.
Trial report in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- On-feet isometric bracing maintains cerebral arterial blood velocity during lower body negative pressure via preload augmentation.Experimental physiology · 2026Trial
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Orthostatic stress reduces venous return and stroke volume (SV), risking cerebral hypoperfusion despite autonomic compensation. Although lower-limb counterpressure manoeuvres improve cerebral perfusion in upright posture, their effects on cerebral blood velocity (CBV) during lower-body negative pressure (LBNP) and the associated mechanisms are not fully defined. We therefore tested whether isometric lower-limb contraction is associated with preservation of CBV during LBNP, accompanied by attenuated effects of preload reduction. Thirteen healthy young adults (age: 25 ± 5 years; 5 women) completed randomized trials under two conditions: off-feet (saddle support, relaxed legs) and on-feet (isometric bracing against a footplate with slight knee flexion). Each condition included 6 min exposures to -30 and -50 mmHg. Systemic vascular conductance declined with increasing LBNP, whereas mean arterial pressure (MAP) was maintained in both conditions. At -50 mmHg, CBV decreased off-feet but was preserved on-feet; SV fell less and the compensatory rise in heart rate (HR) was attenuated on-feet. Repeated-measure correlations showed that CBV tracked SV (r
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Registered trials
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