Evidence map›Paper›PMID 41636495›Full record

ArticleMicrobiology spectrum2026

Impact of contact lenses on the ocular surface microbiome, tear proteome, and dry eye disease.

Oriane S Kopp, Sophia C Morandi, Marco Kreuzer, Anne-Christine Uldry, Nina Eldridge, Martin S Zinkernagel, Denise C Zysset-Burri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oriane S KoppDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0009-4110-4379
Sophia C MorandiDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marco KreuzerInterfaculty Bioinformatics Unit and Swiss Institute of Bioinformatics, University of Bern, Bern, Switzerland.
Anne-Christine UldryDepartment for BioMedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0003-2820-0277
Nina EldridgeDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Martin S ZinkernagelDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Denise C Zysset-BurriDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-4147-5374

Funding

Foundation Bertarelli Catalyst Fund, EPFL (Ecole Polytechnique Fédérale de Lausanne), Lausanne, Switzerland CF10000044-EPFL SCR0237812
6 · The paper itself

Abstract

Although contact lens wear is widespread and known to affect the ocular surface, its impact on the ocular surface microbiome (OSM) remains poorly understood, with existing studies reporting conflicting findings. Additionally, the relationship between contact lens wear, tear proteome, and dry eye disease (DED) is unclear. In this study, we aimed to characterize the OSM (via whole-metagenome shotgun sequencing) and the tear proteome of 25 contact lens wearers and 23 age- and sex-matched controls. The dominant phyla were

Indexed as

BacteriaContact LensesDry Eye SyndromesEyeEye ProteinsMicrobiotaProteomeTearsAdultFemaleHumansMaleYoung AdultEye ProteinsProteometear proteinscontact lensesdry eye diseasenano liquid chromatography tandem mass spectrometryocular surface microbiomewhole-metagenome shotgun sequencing

Identifiers

PMID41636495
PMCPMC12955385

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.